Adipocytes Fraction - GO Biological Process Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Biological Process)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Biological Process)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.05E-06 8 352 1743 1539 9619 1.51E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008152 metabolism 1 249 1743 965 9619 2.40E-10
GO:0006118 electron transport 4 73 1743 248 9619 7.16E-06
GO:0006091 energy pathways 5 30 1743 78 9619 1.79E-05
GO:0006629 lipid metabolism 11 58 1743 213 9619 5.89E-04
GO:0019752 carboxylic acid metabolism 12 31 1743 98 9619 8.22E-04
GO:0007582 physiological process 31 161 1743 752 9619 9.35E-03
GO:0006725 aromatic compound metabolism 83 8 1743 22 9619 3.32E-02
GO:0006692 prostanoid metabolism 103 3 1743 5 9619 4.45E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.04E-05 5 44 1743 120 9619 1.02E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006631 fatty acid metabolism 2 33 1743 79 9619 7.88E-07
GO:0046394 carboxylic acid biosynthesis 6 13 1743 22 9619 2.11E-05
GO:0006633 fatty acid biosynthesis 10 10 1743 17 9619 2.09E-04
GO:0008610 lipid biosynthesis 30 17 1743 52 9619 8.16E-03
GO:0006635 fatty acid beta-oxidation 88 5 1743 11 9619 3.42E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.16E-04 6 29 1743 74 9619 1.62E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006099 tricarboxylic acid cycle 3 12 1743 17 9619 3.03E-06
GO:0006092 main pathways of carbohydrate metabolism 9 23 1743 58 9619 9.63E-05
GO:0006732 coenzyme metabolism 18 8 1743 16 9619 3.69E-03
GO:0006007 glucose catabolism 42 13 1743 38 9619 1.31E-02
GO:0006096 glycolysis 96 10 1743 31 9619 4.16E-02
GO:0006740 NADPH regeneration 104 3 1743 5 9619 4.45E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.62E-03 8 75 1743 293 9619 7.62E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0048193 Golgi vesicle transport 7 20 1743 44 9619 2.67E-05
GO:0045045 secretory pathway 8 27 1743 69 9619 3.24E-05
GO:0015031 protein transport 20 63 1743 253 9619 3.89E-03
GO:0006891 intra-Golgi transport 26 7 1743 14 9619 6.62E-03
GO:0006944 membrane fusion 34 7 1743 15 9619 1.05E-02
GO:0006888 ER to Golgi transport 41 8 1743 19 9619 1.30E-02
GO:0006887 exocytosis 43 13 1743 38 9619 1.31E-02
GO:0048278 vesicle docking 95 4 1743 8 9619 4.06E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.75E-03 2 73 1743 286 9619 9.69E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0046907 intracellular transport 13 68 1743 266 9619 1.36E-03
GO:0006886 intracellular protein transport 25 63 1743 258 9619 6.20E-03
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.10E-03 4 8 1743 14 9619 1.21E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042168 heme metabolism 27 6 1743 11 9619 7.05E-03
GO:0006779 porphyrin biosynthesis 39 6 1743 12 9619 1.20E-02
GO:0006783 heme biosynthesis 55 5 1743 10 9619 2.19E-02
GO:0046138 coenzyme and prosthetic group biosynthesis 81 2 1743 2 9619 3.28E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.35E-03 2 15 1743 38 9619 1.64E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007265 RAS protein signal transduction 16 10 1743 22 9619 2.88E-03
GO:0006913 nucleocytoplasmic transport 63 7 1743 18 9619 3.15E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.54E-03 2 7 1743 12 9619 2.14E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007004 telomerase-dependent telomere maintenance 15 7 1743 12 9619 2.14E-03
GO:0000723 telomere maintenance 14 7 1743 12 9619 2.14E-03
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.54E-03 3 22 1743 66 9619 2.15E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007040 lysosome organization and biogenesis 22 4 1743 5 9619 4.60E-03
GO:0006605 protein targeting 29 19 1743 60 9619 7.80E-03
GO:0006626 protein-mitochondrial targeting 98 7 1743 19 9619 4.23E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.75E-03 4 26 1743 83 9619 2.44E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006417 regulation of protein biosynthesis 17 11 1743 26 9619 3.57E-03
GO:0006445 regulation of translation 38 18 1743 58 9619 1.18E-02
GO:0042254 ribosome biogenesis and assembly 56 5 1743 10 9619 2.19E-02
GO:0009889 regulation of biosynthesis 100 7 1743 19 9619 4.23E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.18E-02 3 17 1743 48 9619 3.25E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006979 response to oxidative stress 21 13 1743 34 9619 4.56E-03
GO:0006800 oxygen and reactive oxygen species metabolism 46 14 1743 43 9619 1.62E-02
GO:0000302 response to reactive oxygen species 50 3 1743 4 9619 2.05E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.30E-02 3 12 1743 30 9619 4.13E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009070 serine family amino acid biosynthesis 19 6 1743 10 9619 3.78E-03
GO:0006545 glycine biosynthesis 66 2 1743 2 9619 3.28E-02
GO:0009165 nucleotide biosynthesis 84 8 1743 22 9619 3.32E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.30E-02 5 125 1743 556 9619 4.22E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006412 protein biosynthesis 28 54 1743 217 9619 7.25E-03
GO:0006418 tRNA aminoacylation for protein translation 40 12 1743 34 9619 1.29E-02
GO:0009059 macromolecule biosynthesis 45 52 1743 215 9619 1.45E-02
GO:0019538 protein metabolism 59 108 1743 502 9619 2.63E-02
GO:0006422 aspartyl-tRNA aminoacylation 65 2 1743 2 9619 3.28E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.39E-02 3 14 1743 38 9619 4.87E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0046034 ATP metabolism 35 9 1743 22 9619 1.06E-02
GO:0009206 purine ribonucleoside triphosphate biosynthesis 54 10 1743 28 9619 2.06E-02
GO:0006754 ATP biosynthesis 87 9 1743 26 9619 3.37E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.49E-02 3 3 1743 3 9619 5.94E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009260 ribonucleotide biosynthesis 23 3 1743 3 9619 5.94E-03
GO:0009124 nucleoside monophosphate biosynthesis 77 2 1743 2 9619 3.28E-02
GO:0009161 ribonucleoside monophosphate metabolism 78 2 1743 2 9619 3.28E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.49E-02 1 3 1743 3 9619 5.94E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030516 regulation of axon extension 24 3 1743 3 9619 5.94E-03
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.00E-02 2 11 1743 29 9619 9.45E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0040029 regulation of gene expression\, epigenetic 92 6 1743 15 9619 3.97E-02
GO:0016582 non-covalent chromatin modification 91 6 1743 15 9619 3.97E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.00E-02 3 171 1743 804 9619 9.72E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006512 ubiquitin cycle 36 25 1743 88 9619 1.15E-02
GO:0006464 protein modification 48 163 1743 778 9619 1.96E-02
GO:0006468 protein amino acid phosphorylation 107 95 1743 446 9619 4.45E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.00E-02 2 14 1743 41 9619 1.04E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009108 coenzyme biosynthesis 32 14 1743 41 9619 1.04E-02
GO:0006753 nucleoside phosphate metabolism 99 7 1743 19 9619 4.23E-02
 
 
 
Cluster 20 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.00E-02 2 7 1743 15 9619 1.05E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0000902 cellular morphogenesis 33 7 1743 15 9619 1.05E-02
GO:0007150 growth pattern 71 2 1743 2 9619 3.28E-02
 
 
 
Cluster 21 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.00E-02 2 7 1743 15 9619 1.05E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009314 response to radiation 61 6 1743 14 9619 2.80E-02
GO:0007255 activation of MAP/ERK kinase kinase 72 2 1743 2 9619 3.28E-02
 
 
 
Cluster 22 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.15E-02 1 4 1743 6 9619 1.18E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006379 mRNA cleavage 37 4 1743 6 9619 1.18E-02
 
 
 
Cluster 23 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.19E-02 3 16 1743 50 9619 1.26E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008203 cholesterol metabolism 62 14 1743 46 9619 2.92E-02
GO:0008354 germ-cell migration 74 2 1743 2 9619 3.28E-02
GO:0016125 sterol metabolism 86 10 1743 30 9619 3.35E-02
 
 
 
Cluster 24 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.27E-02 2 36 1743 139 9619 1.36E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006281 DNA repair 49 35 1743 138 9619 2.03E-02
GO:0006282 regulation of DNA repair 51 3 1743 4 9619 2.05E-02
 
 
 
Cluster 25 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.32E-02 2 28 1743 103 9619 1.45E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006511 ubiquitin-dependent protein catabolism 44 28 1743 103 9619 1.45E-02
GO:0019941 modification-dependent protein catabolism 60 26 1743 99 9619 2.76E-02
 
 
 
Cluster 26 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.81E-02 1 8 1743 20 9619 1.83E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006120 mitochondrial electron transport\, NADH to ubiquinone 47 8 1743 20 9619 1.83E-02
 
 
 
Cluster 27 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.04E-02 3 3 1743 4 9619 2.05E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009083 branched chain family amino acid catabolism 53 3 1743 4 9619 2.05E-02
GO:0006551 leucine metabolism 67 2 1743 2 9619 3.28E-02
GO:0006552 leucine catabolism 68 2 1743 2 9619 3.28E-02
 
 
 
Cluster 28 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.12E-02 4 5 1743 10 9619 2.19E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006572 tyrosine catabolism 52 3 1743 4 9619 2.05E-02
GO:0006558 L-phenylalanine metabolism 57 4 1743 7 9619 2.36E-02
GO:0006559 phenylalanine catabolism 58 4 1743 7 9619 2.36E-02
GO:0009072 aromatic amino acid family metabolism 93 4 1743 8 9619 4.06E-02
 
 
 
Cluster 29 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.90E-02 2 2 1743 2 9619 3.28E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0046473 phosphatidic acid metabolism 82 2 1743 2 9619 3.28E-02
GO:0006654 phosphatidic acid biosynthesis 70 2 1743 2 9619 3.28E-02
 
 
 
Cluster 30 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.90E-02 3 2 1743 2 9619 3.28E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008615 pyridoxine biosynthesis 76 2 1743 2 9619 3.28E-02
GO:0008614 pyridoxine metabolism 75 2 1743 2 9619 3.28E-02
GO:0042819 vitamin B6 biosynthesis 80 2 1743 2 9619 3.28E-02
 
 
 
Cluster 31 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.90E-02 1 2 1743 2 9619 3.28E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006573 valine metabolism 69 2 1743 2 9619 3.28E-02
 
 
 
Cluster 32 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.90E-02 1 2 1743 2 9619 3.28E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007525 somatic muscle development 73 2 1743 2 9619 3.28E-02
 
 
 
Cluster 33 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.90E-02 1 2 1743 2 9619 3.28E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009448 aminobutyrate metabolism 79 2 1743 2 9619 3.28E-02
 
 
 
Cluster 34 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.90E-02 2 8 1743 22 9619 3.32E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006004 fucose metabolism 64 2 1743 2 9619 3.28E-02
GO:0019318 hexose metabolism 85 8 1743 22 9619 3.32E-02
 
 
 
Cluster 35 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.91E-02 1 5 1743 11 9619 3.42E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007031 peroxisome organization and biogenesis 89 5 1743 11 9619 3.42E-02
 
 
 
Cluster 36 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.45E-02 1 4 1743 8 9619 4.06E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009084 glutamine family amino acid biosynthesis 94 4 1743 8 9619 4.06E-02
 
 
 
Cluster 37 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.45E-02 2 7 1743 19 9619 4.23E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006406 mRNA-nucleus export 90 6 1743 15 9619 3.97E-02
GO:0006405 RNA-nucleus export 97 7 1743 19 9619 4.23E-02
 
 
 
Cluster 38 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.45E-02 2 3 1743 5 9619 4.45E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009855 determination of bilateral symmetry 106 3 1743 5 9619 4.45E-02
GO:0007368 determination of left/right symmetry 105 3 1743 5 9619 4.45E-02
 
 
 
Cluster 39 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.45E-02 1 3 1743 5 9619 4.45E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006368 RNA elongation from Pol II promoter 101 3 1743 5 9619 4.45E-02
 
 
 
Cluster 40 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.45E-02 1 3 1743 5 9619 4.45E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006510 ATP-dependent proteolysis 102 3 1743 5 9619 4.45E-02