Stroma Vascular Fraction- GO Biological Process Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Biological Process)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Biological Process)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.23E-11 5 174 1355 634 9619 4.98E-20
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006955 immune response 1 147 1355 469 9619 6.09E-23
GO:0006952 defense response 3 139 1355 442 9619 7.24E-22
GO:0019882 antigen presentation 9 15 1355 26 9619 2.65E-07
GO:0006968 cellular defense response 21 19 1355 61 9619 4.87E-04
GO:0042221 response to chemical substance 49 31 1355 145 9619 1.04E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.00E-10 3 78 1355 262 9619 2.49E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009611 response to wounding 2 70 1355 207 9619 5.62E-12
GO:0006935 chemotaxis 25 26 1355 100 9619 1.14E-03
GO:0009605 response to external stimulus 62 7 1355 22 9619 2.69E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.00E-10 5 334 1355 1745 9619 4.14E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007154 cell communication 8 239 1355 1245 9619 5.29E-08
GO:0007165 signal transduction 10 228 1355 1201 9619 2.95E-07
GO:0007155 cell adhesion 17 97 1355 454 9619 1.01E-05
GO:0007229 integrin-mediated signaling pathway 18 15 1355 39 9619 1.42E-04
GO:0007160 cell-matrix adhesion 27 17 1355 57 9619 1.62E-03
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.00E-10 3 82 1355 285 9619 4.85E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009613 response to pest/pathogen/parasite 4 82 1355 281 9619 3.00E-11
GO:0009615 response to virus 33 12 1355 38 9619 4.57E-03
GO:0006959 humoral immune response 64 9 1355 32 9619 2.86E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.34E-08 3 17 1355 28 9619 1.42E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030333 antigen processing 7 17 1355 28 9619 1.42E-08
GO:0019886 antigen processing\, exogenous antigen via MHC class II 12 11 1355 16 9619 9.22E-07
GO:0019884 antigen presentation\, exogenous antigen 11 11 1355 16 9619 9.22E-07
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.35E-07 4 63 1355 232 9619 9.73E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006954 inflammatory response 5 54 1355 159 9619 1.32E-10
GO:0045087 innate immune response 6 52 1355 154 9619 4.02E-10
GO:0042330 taxis 22 26 1355 97 9619 6.94E-04
GO:0007204 cytosolic calcium ion concentration elevation 63 10 1355 37 9619 2.83E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.24E-05 3 28 1355 81 9619 2.63E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019735 antimicrobial humoral response (sensu Vertebrata) 13 27 1355 77 9619 2.90E-06
GO:0016064 humoral defense mechanism (sensu Vertebrata) 14 27 1355 79 9619 5.06E-06
GO:0019730 antimicrobial humoral response 15 26 1355 75 9619 5.61E-06
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.90E-05 2 52 1355 202 9619 7.03E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007264 small GTPase mediated signal transduction 16 52 1355 202 9619 7.03E-06
GO:0007266 Rho protein signal transduction 39 8 1355 21 9619 5.61E-03
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.43E-03 3 22 1355 80 9619 1.21E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006897 endocytosis 31 20 1355 77 9619 4.09E-03
GO:0015884 folate transport 46 3 1355 4 9619 9.98E-03
GO:0006898 receptor mediated endocytosis 66 6 1355 18 9619 3.17E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.49E-03 2 46 1355 216 9619 2.28E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042127 regulation of cell proliferation 28 46 1355 216 9619 2.28E-03
GO:0008284 positive regulation of cell proliferation 35 23 1355 94 9619 4.89E-03
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.49E-03 2 75 1355 389 9619 2.36E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006357 regulation of transcription from Pol II promoter 20 46 1355 200 9619 4.14E-04
GO:0006366 transcription from Pol II promoter 40 64 1355 336 9619 6.31E-03
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.49E-03 3 13 1355 40 9619 2.41E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030005 di-\, tri-valent inorganic cation homeostasis 23 13 1355 36 9619 7.97E-04
GO:0006874 calcium ion homeostasis 26 9 1355 21 9619 1.26E-03
GO:0006875 metal ion homeostasis 36 9 1355 25 9619 5.19E-03
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.49E-03 2 10 1355 27 9619 2.56E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006956 complement activation 29 10 1355 27 9619 2.56E-03
GO:0006958 complement activation\, classical pathway 56 7 1355 21 9619 2.08E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.97E-03 1 10 1355 28 9619 3.48E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006487 N-linked glycosylation 30 10 1355 28 9619 3.48E-03
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.97E-03 3 59 1355 298 9619 3.62E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006915 apoptosis 37 51 1355 255 9619 5.32E-03
GO:0012501 programmed cell death 55 39 1355 200 9619 2.01E-02
GO:0043066 negative regulation of apoptosis 67 16 1355 71 9619 3.57E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.57E-03 2 4 1355 6 9619 4.64E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009168 purine ribonucleoside monophosphate biosynthesis 34 4 1355 6 9619 4.64E-03
GO:0009127 purine nucleoside monophosphate biosynthesis 44 3 1355 4 9619 9.98E-03
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.00E-02 2 9 1355 25 9619 5.19E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008219 cell death 42 8 1355 22 9619 7.75E-03
GO:0016265 death 52 5 1355 12 9619 1.85E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.00E-02 2 6 1355 13 9619 5.46E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043062 extracellular structure organization and biogenesis 32 5 1355 9 9619 4.23E-03
GO:0030198 extracellular matrix organization and biogenesis 38 6 1355 13 9619 5.46E-03
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.35E-02 3 22 1355 92 9619 7.76E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019885 antigen processing\, endogenous antigen via MHC class I 24 6 1355 10 9619 9.76E-04
GO:0019883 antigen presentation\, endogenous antigen 41 5 1355 10 9619 7.49E-03
GO:0006461 protein complex assembly 77 18 1355 85 9619 4.72E-02
 
 
 
Cluster 20 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.39E-02 2 6 1355 14 9619 8.43E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006477 protein amino acid sulfation 70 3 1355 6 9619 4.01E-02
GO:0006476 protein amino acid deacetylation 72 4 1355 10 9619 4.07E-02
 
 
 
Cluster 21 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.44E-02 5 212 1355 1304 9619 9.42E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008283 cell proliferation 19 81 1355 400 9619 3.50E-04
GO:0009987 cellular process 43 76 1355 417 9619 9.51E-03
GO:0016049 cell growth 61 18 1355 79 9619 2.43E-02
GO:0006928 cell motility 68 32 1355 166 9619 3.79E-02
GO:0008151 cell growth and/or maintenance 69 139 1355 860 9619 3.90E-02
 
 
 
Cluster 22 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.44E-02 2 4 1355 7 9619 9.62E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030201 heparan sulfate proteoglycan metabolism 47 3 1355 4 9619 9.98E-03
GO:0015012 heparan sulfate proteoglycan biosynthesis 59 3 1355 5 9619 2.23E-02
 
 
 
Cluster 23 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.78E-02 2 6 1355 15 9619 1.24E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006909 phagocytosis 50 6 1355 15 9619 1.24E-02
GO:0008228 opsonization 53 2 1355 2 9619 1.98E-02
 
 
 
Cluster 24 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.17E-02 2 7 1355 20 9619 1.57E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042113 B-cell activation 51 7 1355 20 9619 1.57E-02
GO:0030183 B-cell differentiation 73 4 1355 10 9619 4.07E-02
 
 
 
Cluster 25 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.62E-02 1 2 1355 2 9619 1.98E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0050651 dermatan sulfate proteoglycan biosynthesis 54 2 1355 2 9619 1.98E-02
 
 
 
Cluster 26 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.81E-02 2 3 1355 5 9619 2.23E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0045843 negative regulation of myogenesis 48 3 1355 4 9619 9.98E-03
GO:0016202 regulation of myogenesis 60 3 1355 5 9619 2.23E-02
 
 
 
Cluster 27 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.81E-02 2 82 1355 472 9619 2.30E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007167 enzyme linked receptor protein signaling pathway 57 16 1355 67 9619 2.15E-02
GO:0006468 protein amino acid phosphorylation 65 77 1355 446 9619 3.07E-02
 
 
 
Cluster 28 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.68E-02 1 6 1355 19 9619 4.10E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006753 nucleoside phosphate metabolism 74 6 1355 19 9619 4.10E-02
 
 
 
Cluster 29 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.68E-02 1 22 1355 107 9619 4.12E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0001501 skeletal development 75 22 1355 107 9619 4.12E-02
 
 
 
Cluster 30 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.68E-02 1 40 1355 217 9619 4.25E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006412 protein biosynthesis 76 40 1355 217 9619 4.25E-02