Adipocytes Fraction- GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.56E-11 6 140 1874 398 10281 2.04E-12
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016491 oxidoreductase activity 3 136 1874 382 10281 8.16E-12
GO:0015081 sodium ion transporter activity 11 18 1874 34 10281 5.10E-06
GO:0016616 oxidoreductase activity\, acting on the CH-OH group of donors\, NAD or NADP as acceptor 25 15 1874 41 10281 4.15E-03
GO:0016634 oxidoreductase activity\, acting on the CH-CH group of donors\, oxygen as acceptor 60 4 1874 7 10281 2.41E-02
GO:0004024 alcohol dehydrogenase activity\, zinc-dependent 106 6 1874 15 10281 4.08E-02
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity 117 3 1874 5 10281 4.52E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.54E-12 6 85 1874 216 10281 3.12E-13
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005489 electron transporter activity 1 71 1874 171 10281 1.07E-11
GO:0015399 primary active transporter activity 6 31 1874 62 10281 1.23E-08
GO:0015036 disulfide oxidoreductase activity 40 8 1874 18 10281 9.25E-03
GO:0008746 NAD(P) transhydrogenase activity 87 2 1874 2 10281 3.32E-02
GO:0009053 electron donor activity 88 2 1874 2 10281 3.32E-02
GO:0030508 thiol-disulfide exchange intermediate activity 93 2 1874 2 10281 3.32E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.55E-10 8 650 1874 2818 10281 1.11E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003824 catalytic activity 2 551 1874 2321 10281 1.80E-12
GO:0030554 adenyl nucleotide binding 13 219 1874 971 10281 1.97E-04
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 44 4 1874 6 10281 1.21E-02
GO:0004674 protein serine/threonine kinase activity 53 73 1874 320 10281 2.06E-02
GO:0005506 iron ion binding 101 9 1874 26 10281 3.49E-02
GO:0016740 transferase activity 103 190 1874 929 10281 3.75E-02
GO:0003950 NAD+ ADP-ribosyltransferase activity 107 4 1874 8 10281 4.14E-02
GO:0016829 lyase activity 115 22 1874 84 10281 4.40E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.36E-07 7 44 1874 105 10281 1.29E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003954 NADH dehydrogenase activity 4 17 1874 21 10281 7.31E-10
GO:0015078 hydrogen ion transporter activity 7 40 1874 98 10281 1.39E-07
GO:0008137 NADH dehydrogenase (ubiquinone) activity 9 18 1874 31 10281 8.34E-07
GO:0004129 cytochrome-c oxidase activity 95 8 1874 22 10281 3.43E-02
GO:0015002 heme-copper terminal oxidase activity 96 8 1874 22 10281 3.43E-02
GO:0016676 oxidoreductase activity\, acting on heme group of donors\, oxygen as acceptor 97 8 1874 22 10281 3.43E-02
GO:0005217 intracellular ligand-gated ion channel activity 102 5 1874 11 10281 3.50E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.41E-07 6 58 1874 164 10281 1.12E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016874 ligase activity 8 45 1874 121 10281 5.84E-07
GO:0016883 other carbon-nitrogen ligase activity 39 6 1874 11 10281 7.27E-03
GO:0004842 ubiquitin-protein ligase activity 52 22 1874 78 10281 1.99E-02
GO:0004840 ubiquitin conjugating enzyme activity 65 15 1874 50 10281 2.92E-02
GO:0004776 succinate-CoA ligase (GDP-forming) activity 82 2 1874 2 10281 3.32E-02
GO:0004815 aspartate-tRNA ligase activity 83 2 1874 2 10281 3.32E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.86E-06 2 20 1874 37 10281 9.80E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016659 oxidoreductase activity\, acting on NADH or NADPH\, other acceptor 5 17 1874 22 10281 2.65E-09
GO:0016655 oxidoreductase activity\, acting on NADH or NADPH\, quinone or similar compound as acceptor 10 19 1874 35 10281 1.68E-06
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.02E-05 4 166 1874 669 10281 6.71E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005215 transporter activity 12 158 1874 652 10281 4.38E-05
GO:0008565 protein transporter activity 16 61 1874 227 10281 7.38E-04
GO:0005319 lipid transporter activity 41 13 1874 37 10281 1.08E-02
GO:0015457 auxiliary transport protein activity 89 2 1874 2 10281 3.32E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.00E-03 3 240 1874 1076 10281 1.98E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005524 ATP binding 14 218 1874 968 10281 2.23E-04
GO:0004812 tRNA ligase activity 50 12 1874 34 10281 1.36E-02
GO:0016301 kinase activity 121 50 1874 219 10281 4.79E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.00E-03 3 6 1874 7 10281 2.15E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004300 enoyl-CoA hydratase activity 26 4 1874 5 10281 4.70E-03
GO:0016453 C-acetyltransferase activity 33 3 1874 3 10281 6.05E-03
GO:0003985 acetyl-CoA C-acetyltransferase activity 72 2 1874 2 10281 3.32E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.99E-03 2 7 1874 10 10281 4.74E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016628 oxidoreductase activity\, acting on the CH-CH group of donors\, NAD or NADP as acceptor 15 7 1874 10 10281 4.74E-04
GO:0047115 trans-1\,2-dihydrobenzene-1\,2-diol dehydrogenase activity 19 4 1874 4 10281 1.10E-03
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.78E-03 5 6 1874 8 10281 7.28E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016421 CoA carboxylase activity 18 5 1874 6 10281 1.02E-03
GO:0009374 biotin binding 17 5 1874 6 10281 1.02E-03
GO:0004075 biotin carboxylase activity 54 3 1874 4 10281 2.09E-02
GO:0004485 methylcrotonoyl-CoA carboxylase activity 80 2 1874 2 10281 3.32E-02
GO:0003989 acetyl-CoA carboxylase activity 73 2 1874 2 10281 3.32E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.57E-03 3 5 1874 6 10281 1.02E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016832 aldehyde-lyase activity 34 3 1874 3 10281 6.05E-03
GO:0016228 aldolase activity 32 3 1874 3 10281 6.05E-03
GO:0016830 carbon-carbon lyase activity 56 3 1874 4 10281 2.09E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.96E-03 3 6 1874 9 10281 1.85E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008172 S-methyltransferase activity 27 4 1874 5 10281 4.70E-03
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity 69 2 1874 2 10281 3.32E-02
GO:0009008 DNA-methyltransferase activity 118 3 1874 5 10281 4.52E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.84E-03 3 8 1874 15 10281 2.28E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016891 endoribonuclease activity\, producing 5'-phosphomonoesters 20 7 1874 12 10281 2.22E-03
GO:0004526 ribonuclease P activity 43 4 1874 6 10281 1.21E-02
GO:0004549 tRNA-specific ribonuclease activity 49 5 1874 9 10281 1.32E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.49E-03 1 5 1874 7 10281 3.03E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0000339 RNA cap binding 21 5 1874 7 10281 3.03E-03
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.96E-03 4 13 1874 33 10281 3.56E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016684 oxidoreductase activity\, acting on peroxide as acceptor 62 9 1874 25 10281 2.71E-02
GO:0004096 catalase activity 74 2 1874 2 10281 3.32E-02
GO:0048156 tau protein binding 94 2 1874 2 10281 3.32E-02
GO:0016209 antioxidant activity 100 10 1874 30 10281 3.47E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.96E-03 2 8 1874 16 10281 3.84E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016637 oxidoreductase activity\, acting on the CH-CH group of donors\, other acceptors 48 6 1874 12 10281 1.23E-02
GO:0003995 acyl-CoA dehydrogenase activity 57 5 1874 10 10281 2.24E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.96E-03 1 38 1874 137 10281 3.84E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003735 structural constituent of ribosome 24 38 1874 137 10281 3.84E-03
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.35E-02 4 23 1874 75 10281 6.09E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015405 P-P-bond-hydrolysis-driven transporter activity 35 23 1874 75 10281 6.09E-03
GO:0015450 protein translocase activity 64 6 1874 14 10281 2.88E-02
GO:0004009 ATP-binding cassette (ABC) transporter activity 98 15 1874 51 10281 3.46E-02
GO:0042626 ATPase activity\, coupled to transmembrane movement of substances 105 15 1874 52 10281 4.07E-02
 
 
 
Cluster 20 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.35E-02 2 10 1874 24 10281 6.44E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004702 receptor signaling protein serine/threonine kinase activity 36 10 1874 24 10281 6.44E-03
GO:0004707 MAP kinase activity 47 6 1874 12 10281 1.23E-02
 
 
 
Cluster 21 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.04E-02 2 348 1874 1719 10281 1.02E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0000166 nucleotide binding 37 32 1874 115 10281 7.19E-03
GO:0005488 binding 42 347 1874 1716 10281 1.10E-02
 
 
 
Cluster 22 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.20E-02 2 4 1874 6 10281 1.21E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005484 SNAP receptor activity 45 4 1874 6 10281 1.21E-02
GO:0005486 t-SNARE activity 84 2 1874 2 10281 3.32E-02
 
 
 
Cluster 23 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.20E-02 3 6 1874 12 10281 1.23E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004091 carboxylesterase activity 46 6 1874 12 10281 1.23E-02
GO:0004759 serine esterase activity 58 5 1874 10 10281 2.24E-02
GO:0016289 CoA hydrolase activity 119 3 1874 5 10281 4.52E-02
 
 
 
Cluster 24 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.20E-02 2 18 1874 58 10281 1.26E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016818 hydrolase activity\, acting on acid anhydrides\, in phosphorus-containing anhydrides 28 15 1874 42 10281 5.38E-03
GO:0016887 ATPase activity 67 12 1874 38 10281 3.31E-02
 
 
 
Cluster 25 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.06E-02 3 8 1874 20 10281 1.89E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004046 aminoacylase activity 29 3 1874 3 10281 6.05E-03
GO:0017068 glutamyl-tRNA(Gln) amidotransferase activity 91 2 1874 2 10281 3.32E-02
GO:0016811 hydrolase activity\, acting on carbon-nitrogen (but not peptide) bonds\, in linear amides 114 7 1874 19 10281 4.35E-02
 
 
 
Cluster 26 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.06E-02 3 29 1874 109 10281 1.89E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016881 acid-D-amino acid ligase activity 63 25 1874 94 10281 2.80E-02
GO:0019787 ubiquitin-like-protein ligase activity 92 2 1874 2 10281 3.32E-02
GO:0008639 small protein conjugating enzyme activity 99 15 1874 51 10281 3.46E-02
 
 
 
Cluster 27 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.25E-02 2 3 1874 4 10281 2.09E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004448 isocitrate dehydrogenase activity 55 3 1874 4 10281 2.09E-02
GO:0004449 isocitrate dehydrogenase (NAD+) activity 78 2 1874 2 10281 3.32E-02
 
 
 
Cluster 28 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.36E-02 2 5 1874 10 10281 2.24E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016646 oxidoreductase activity\, acting on the CH-NH group of donors\, NAD or NADP as acceptor 59 5 1874 10 10281 2.24E-02
GO:0004146 dihydrofolate reductase activity 77 2 1874 2 10281 3.32E-02
 
 
 
Cluster 29 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.38E-02 5 19 1874 66 10281 2.36E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016411 acylglycerol O-acyltransferase activity 23 5 1874 7 10281 3.03E-03
GO:0004144 diacylglycerol O-acyltransferase activity 76 2 1874 2 10281 3.32E-02
GO:0004469 lysophosphatidate acyltransferase activity 79 2 1874 2 10281 3.32E-02
GO:0008415 acyltransferase activity 104 18 1874 65 10281 3.92E-02
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 116 3 1874 5 10281 4.52E-02
 
 
 
Cluster 30 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.38E-02 2 4 1874 7 10281 2.41E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008339 MP kinase activity 31 3 1874 3 10281 6.05E-03
GO:0016909 SAP kinase activity 61 4 1874 7 10281 2.41E-02
 
 
 
Cluster 31 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.77E-02 1 12 1874 38 10281 3.31E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005069 transmembrane receptor protein tyrosine kinase docking protein activity 66 12 1874 38 10281 3.31E-02
 
 
 
Cluster 32 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.77E-02 2 2 1874 2 10281 3.32E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003910 DNA ligase (ATP) activity 71 2 1874 2 10281 3.32E-02
GO:0003909 DNA ligase activity 70 2 1874 2 10281 3.32E-02
 
 
 
Cluster 33 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.77E-02 1 2 1874 2 10281 3.32E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004108 citrate (Si)-synthase activity 75 2 1874 2 10281 3.32E-02
 
 
 
Cluster 34 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.77E-02 1 2 1874 2 10281 3.32E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004597 peptide-aspartate beta-dioxygenase activity 81 2 1874 2 10281 3.32E-02
 
 
 
Cluster 35 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.77E-02 1 2 1874 2 10281 3.32E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005546 phosphatidylinositol-4\,5-bisphosphate binding 85 2 1874 2 10281 3.32E-02
 
 
 
Cluster 36 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.77E-02 1 2 1874 2 10281 3.32E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008462 endopeptidase Clp activity 86 2 1874 2 10281 3.32E-02
 
 
 
Cluster 37 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.77E-02 1 2 1874 2 10281 3.32E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016499 orexin receptor activity 90 2 1874 2 10281 3.32E-02
 
 
 
Cluster 38 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.83E-02 4 15 1874 51 10281 3.46E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003708 retinoic acid receptor activity 22 5 1874 7 10281 3.03E-03
GO:0004886 retinoid-X receptor activity 30 3 1874 3 10281 6.05E-03
GO:0004879 ligand-dependent nuclear receptor activity 51 15 1874 47 10281 1.67E-02
GO:0003707 steroid hormone receptor activity 113 14 1874 48 10281 4.32E-02
 
 
 
Cluster 39 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.34E-02 2 4 1874 8 10281 4.14E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003863 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 68 2 1874 2 10281 3.32E-02
GO:0016624 oxidoreductase activity\, acting on the aldehyde or oxo group of donors\, disulfide as acceptor 110 4 1874 8 10281 4.14E-02
 
 
 
Cluster 40 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.34E-02 2 4 1874 8 10281 4.14E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016681 oxidoreductase activity\, acting on diphenols and related substances as donors\, cytochrome as acceptor 111 4 1874 8 10281 4.14E-02
GO:0008121 ubiquinol-cytochrome-c reductase activity 108 4 1874 8 10281 4.14E-02
 
 
 
Cluster 41 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.42E-02 3 10 1874 31 10281 4.32E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009055 electron carrier activity 38 6 1874 11 10281 7.27E-03
GO:0008320 protein carrier activity 109 4 1874 8 10281 4.14E-02
GO:0005386 carrier activity 112 10 1874 31 10281 4.32E-02
 
 
 
Cluster 42 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.54E-02 1 85 1874 393 10281 4.54E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005554 molecular_function unknown 120 85 1874 393 10281 4.54E-02