Stroma Vascular Fraction- GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.37E-07 7 220 1395 1146 10281 9.86E-09
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0045012 MHC class II receptor activity 1 11 1395 17 10281 1.56E-06
GO:0004888 transmembrane receptor activity 9 66 1395 310 10281 9.87E-05
GO:0004871 signal transducer activity 10 155 1395 869 10281 1.23E-04
GO:0005057 receptor signaling protein activity 13 19 1395 62 10281 3.79E-04
GO:0004872 receptor activity 14 133 1395 750 10281 4.89E-04
GO:0015026 coreceptor activity 24 7 1395 15 10281 1.98E-03
GO:0005055 laminin receptor activity 49 2 1395 2 10281 1.84E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.52E-04 3 8 1395 11 10281 1.27E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019865 immunoglobulin binding 2 8 1395 11 10281 1.27E-05
GO:0019864 IgG binding 11 5 1395 6 10281 2.43E-04
GO:0019863 IgE binding 35 3 1395 4 10281 8.96E-03
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.27E-04 7 210 1395 1203 10281 2.83E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005515 protein binding 4 206 1395 1185 10281 4.46E-05
GO:0005516 calmodulin binding 32 22 1395 95 10281 7.45E-03
GO:0030674 protein binding\, bridging 41 4 1395 8 10281 1.50E-02
GO:0005518 collagen binding 42 5 1395 12 10281 1.58E-02
GO:0030617 transforming growth factor beta receptor\, inhibitory cytoplasmic mediator activity 54 2 1395 2 10281 1.84E-02
GO:0019213 deacetylase activity 56 5 1395 13 10281 2.29E-02
GO:0005178 integrin binding 67 7 1395 25 10281 4.38E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.35E-04 6 42 1395 167 10281 3.92E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005125 cytokine activity 3 42 1395 167 10281 3.92E-05
GO:0008009 chemokine activity 6 16 1395 43 10281 8.66E-05
GO:0042056 chemoattractant activity 7 16 1395 43 10281 8.66E-05
GO:0042379 chemokine receptor binding 8 16 1395 43 10281 8.66E-05
GO:0005164 tumor necrosis factor receptor binding 20 8 1395 18 10281 1.39E-03
GO:0005138 interleukin-6 receptor binding 50 2 1395 2 10281 1.84E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.61E-04 6 46 1395 198 10281 1.38E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005096 GTPase activator activity 5 26 1395 89 10281 8.48E-05
GO:0008047 enzyme activator activity 17 26 1395 101 10281 7.61E-04
GO:0046582 Rap GTPase activator activity 26 3 1395 3 10281 2.49E-03
GO:0030695 GTPase regulator activity 27 22 1395 88 10281 2.79E-03
GO:0005095 GTPase inhibitor activity 55 3 1395 5 10281 2.01E-02
GO:0005085 guanyl-nucleotide exchange factor activity 64 14 1395 63 10281 4.02E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.68E-03 4 81 1395 417 10281 4.21E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003712 transcription cofactor activity 23 43 1395 204 10281 1.88E-03
GO:0003702 RNA polymerase II transcription factor activity 37 33 1395 164 10281 1.21E-02
GO:0003713 transcription coactivator activity 43 26 1395 125 10281 1.61E-02
GO:0004386 helicase activity 69 17 1395 82 10281 4.67E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.22E-03 3 22 1395 80 10281 7.30E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005201 extracellular matrix structural constituent 15 22 1395 79 10281 6.05E-04
GO:0008147 structural constituent of bone 34 3 1395 4 10281 8.96E-03
GO:0030023 extracellular matrix constituent conferring elasticity 53 2 1395 2 10281 1.84E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.22E-03 2 20 1395 70 10281 7.39E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005539 glycosaminoglycan binding 16 20 1395 70 10281 7.39E-04
GO:0008201 heparin binding 28 15 1395 52 10281 2.96E-03
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.14E-03 4 61 1395 307 10281 1.18E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019001 guanyl nucleotide binding 19 52 1395 252 10281 1.11E-03
GO:0003925 small monomeric GTPase activity 21 33 1395 145 10281 1.66E-03
GO:0003924 GTPase activity 30 32 1395 148 10281 4.51E-03
GO:0016817 hydrolase activity\, acting on acid anhydrides 59 12 1395 49 10281 2.78E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.15E-03 1 11 1395 31 10281 1.73E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003823 antigen binding 22 11 1395 31 10281 1.73E-03
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.62E-03 2 8 1395 19 10281 2.12E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019838 growth factor binding 25 8 1395 19 10281 2.12E-03
GO:0005520 insulin-like growth factor binding 29 7 1395 16 10281 3.11E-03
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.26E-03 3 54 1395 278 10281 3.63E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005525 GTP binding 18 52 1395 251 10281 1.01E-03
GO:0003928 RAB small monomeric GTPase activity 36 12 1395 44 10281 1.20E-02
GO:0050800 hydrolase activity\, acting on acid anhydrides\, acting on GTP\, involved in cellular and subcellular movement 65 24 1395 123 10281 4.04E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.20E-02 2 71 1395 404 10281 1.19E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004672 protein kinase activity 31 69 1395 379 10281 5.81E-03
GO:0004674 protein serine/threonine kinase activity 58 56 1395 320 10281 2.54E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.37E-02 2 13 1395 50 10281 1.38E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005021 vascular endothelial growth factor receptor activity 12 6 1395 9 10281 3.59E-04
GO:0004714 transmembrane receptor protein tyrosine kinase activity 38 13 1395 50 10281 1.38E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.40E-02 2 4 1395 8 10281 1.50E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004681 casein kinase I activity 33 3 1395 4 10281 8.96E-03
GO:0004680 casein kinase activity 39 4 1395 8 10281 1.50E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.45E-02 1 2 1395 2 10281 1.84E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity 46 2 1395 2 10281 1.84E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.45E-02 1 2 1395 2 10281 1.84E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004850 uridine phosphorylase activity 47 2 1395 2 10281 1.84E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.45E-02 1 2 1395 2 10281 1.84E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004947 bradykinin receptor activity 48 2 1395 2 10281 1.84E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.05E-02 2 4 1395 9 10281 2.41E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015149 hexose transporter activity 40 4 1395 8 10281 1.50E-02
GO:0005355 glucose transporter activity 57 4 1395 9 10281 2.41E-02
 
 
 
Cluster 20 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.65E-02 2 64 1395 376 10281 3.05E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004540 ribonuclease activity 60 5 1395 14 10281 3.17E-02
GO:0003723 RNA binding 66 62 1395 370 10281 4.32E-02
 
 
 
Cluster 21 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.95E-02 1 6 1395 19 10281 3.49E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008373 sialyltransferase activity 61 6 1395 19 10281 3.49E-02
 
 
 
Cluster 22 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.95E-02 2 3 1395 6 10281 3.63E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008511 sodium\:chloride/potassium\:chloride symporter activity 51 2 1395 2 10281 1.84E-02
GO:0015377 cation\:chloride symporter activity 62 3 1395 6 10281 3.63E-02
 
 
 
Cluster 23 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.95E-02 1 17 1395 80 10281 3.79E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004197 cysteine-type endopeptidase activity 63 17 1395 80 10281 3.79E-02
 
 
 
Cluster 24 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.39E-02 4 24 1395 124 10281 4.39E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004263 chymotrypsin activity 44 19 1395 85 10281 1.78E-02
GO:0004295 trypsin activity 45 20 1395 91 10281 1.83E-02
GO:0030019 tryptase activity 52 2 1395 2 10281 1.84E-02
GO:0004252 serine-type endopeptidase activity 68 24 1395 124 10281 4.39E-02