| Cluster Query pathways - Genes |
| 1,4-Dichlorobenzene degradation |
CYP39A1 |
| 2,4-Dichlorobenzoate degradation |
LIPE PRDX6 |
| ATP synthesis |
ATP5B ATP5D ATP5J ATP5O
ATP6V1C1 ATP6V1E1 ATP5C1 ATP5J2
ATP6V0E ATP6V1A ATP6V1D ATP6V0A2
|
| Alanine and aspartate metabolism |
GPT ASS ABAT DDO
ADSL ASPA DARS |
| Alkaloid biosynthesis I |
CYP39A1 |
| Alkaloid biosynthesis II |
AOC3 |
| Alzheimer's disease |
INSR APOE GNG10 GNG12
PSEN2 GSK3B LPL APPBP1
UBQLN1 |
| Aminoacyl-tRNA biosynthesis |
RARS TARS CARS KARS
MARS WARS2 DARS HARS
|
| Aminophosphonate metabolism |
FTSJ1 |
| Aminosugars metabolism |
HK2 MTMR2 GFPT1 CTBS
PGM3 |
| Amyotrophic lateral sclerosis (ALS) |
PPP3CA BAD KARS SOD1
|
| Androgen and estrogen metabolism |
UGT2B7 CYP11B1 SRD5A2 CYP39A1
FTSJ1 |
| Apoptosis |
CASP6 BCL2L2 BAD FADD
PTPN13 |
| Arginine and proline metabolism |
AOC3 RARS ASS ALDH2
CKB MAOA MAOB CKMT2
ALDH1A1 ALDH1B1 ALDH3A2 |
| Ascorbate and aldarate metabolism |
ALDH2 CYP26A1 ALDH1A1 ALDH1B1
LTB4DH ALDH3A2 |
| Basal transcription factors |
TAF10 TAF12 TAF6L TAF7L
GTF2A2 GTF2E1 GTF2E2 GTF2H3
GTF2H4 |
| Benzoate degradation via CoA ligation |
CSNK1G1 DHRS2 PAK4 TESK2
ACAT1 ULK1 ECHS1 BCR
HIPK2 HADH2 HADHA STK39
ARD1 CDKL1 GCDH AKT2
PRKCD PRKCE CDK5 CDK8
CDK9 CLK3 LTB4DH HADHSC
MAP2K7 |
| Benzoate degradation via hydroxylation |
ACAA1 ECH1 |
| Bile acid biosynthesis |
ACAA1 ALDH2 SRD5A2 CYP39A1
ACADSB ADH1B ADH1C ADH4
ADH6 ALDH1A1 ALDH1B1 LTB4DH
ALDH3A2 |
| Biotin metabolism |
BTD |
| Blood group glycolipid biosynthesis-lactoseries |
OGT |
| Blood group glycolipid biosynthesis-neolactoseries |
OGT SIAT8B B3GNT6 |
| Butanoate metabolism |
ACADS LIPE ACAT1 ALDH5A1
AACS ALDH2 ECHS1 BDH
ABAT HADH2 HADHA PDHB
ARD1 ALDH1A1 ALDH1B1 PRDX6
LTB4DH PDHA1 HADHSC ALDH3A2
|
| C21-Steroid hormone metabolism |
CYP11B1 |
| Carbon fixation |
GPT ALDOA ALDOB ALDOC
ME1 MDH1 MDH2 |
| Cell cycle |
CDC14B CDKN1C BUB3 YWHAG
GSK3B CCNH SMC1L1 |
| Chondroitin / Heparan sulfate biosynthesis |
B4GALT7 XYLT1 NDST2 |
| Circadian rhythm |
NR1D1 BHLHB3 NPAS2 |
| Citrate cycle (TCA cycle) |
SDHA SDHC PCK2 ACLY
ACO1 DLD IDH3A IDH3B
IDH3G SUCLG1 SUCLG2 IDH2
MDH1 MDH2 |
| Complement and coagulation cascades |
SERPINF2 C4BPB C6 |
| Cysteine metabolism |
CARS LDHA CTH MPST
|
| D-Arginine and D-ornithine metabolism |
ARD1 |
| DNA polymerase |
POLE POLH POLM POLD2
POLD4 REV1L |
| Dentatorubropallidoluysian atrophy (DRPLA) |
INSR AIP1 WWP2 DRPLA
|
| Erythromycin biosynthesis |
HK2 |
| Ethylbenzene degradation |
DHRS2 ARD1 |
| Fatty acid biosynthesis (path 1) |
ACACA ACACB |
| Fatty acid biosynthesis (path 2) |
ACAA1 ACAT1 ECHS1 HADH2
HADHA HADHSC |
| Fatty acid metabolism |
CPT1A ACAA1 ACOX1 ACADS
ACAT1 ALDH2 CYP2B6 ECHS1
CYP3A7 ADH1B ADH1C HADH2
HADHA CYP4F8 GCDH ADH4
CYP4F11 ADH6 CYP4F12 ALDH1A1
ALDH1B1 HADHSC ALDH3A2 |
| Flavonoids, stilbene and lignin biosynthesis |
CYP39A1 CYP26A1 PRDX6 MPO
|
| Fluorene degradation |
CYP26A1 ECH1 |
| Folate biosynthesis |
MTHFD1 DHFR ALPI |
| Fructose and mannose metabolism |
OGT HK2 PFKFB3 MTMR2
ALDOA ALDOB ALDOC TSTA3
PMM1 LTB4DH FPGT |
| Galactose metabolism |
HK2 GALE UGP2 LTB4DH
|
| Ganglioside biosynthesis |
OGT SIAT4B SIAT8B |
| Globoside metabolism |
OGT SIAT4B SIAT8B |
| Glutamate metabolism |
GPT GSS ALDH5A1 ABAT
GFPT1 GCLC GLUL |
| Glutathione metabolism |
GSS MGST1 MGST3 GPX1
GPX2 GCLC IDH2 GSTM2
GSTP1 GSTT1 GSTZ1 |
| Glycerolipid metabolism |
CPT1A AGPAT1 AGPAT2 AGPAT3
PLA2G1B OGT PPAP2B DGAT1
ALDH2 PISD PAFAH1B1 PAFAH1B2
GPD1 PAFAH2 ADH1B ADH1C
ARD1 DGKG ADH4 DGKZ
ADH6 ALDH1A1 ALDH1B1 LPL
ALPI LTB4DH ALDH3A2 |
| Glycine, serine and threonine metabolism |
DMGDH AOC3 TARS PISD
MAOA MAOB DLD GCAT
PEMT LTB4DH PSAT1 |
| Glycolysis / Gluconeogenesis |
GPI ENO1 HK2 ACAS2
ALDH2 ALDOA ALDOB ALDOC
DLAT LDHA ADH1B ADH1C
PDHB PDHX DLD ADH4
ADH6 ALDH1A1 ALDH1B1 PDHA1
ALDH3A2 |
| Glycosaminoglycan degradation |
GNS ARSB CTBS |
| Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
OGT LIPE PIGC PIGS
GPAA1 DSCR5 PRDX6 |
| Glyoxylate and dicarboxylate metabolism |
MTHFD1 ACO1 GRHPR HAO1
MDH1 MDH2 |
| Histidine metabolism |
AOC3 ALDH2 CYP39A1 ARD1
MAOA MAOB ALDH1A1 ALDH1B1
ASPA ALDH3A2 FTSJ1 HARS
|
| Huntington's disease |
HIP1 HIP2 CASP6 CALM3
DCTN1 GRB2 CLTA CLTB
|
| Inositol metabolism |
ALDH6A1 |
| Inositol phosphate metabolism |
CSNK1G1 PAK4 TESK2 ULK1
PIK3C2G BCR HIPK2 PLCB1
PIK3CB INPP5A STK39 CDKL1
AKT2 PRKCD PRKCE IMPA2
CDK5 CDK8 CDK9 CLK3
MAP2K7 |
| Integrin-mediated cell adhesion |
PAK4 HRAS CAPNS1 CAV1
CAV2 ARHGEF6 ARHGEF7 CRK
SHC1 MAPK4 SOS1 AKT2
GRB2 PTK2 TLN1 |
| Keratan sulfate biosynthesis |
OGT |
| Lysine biosynthesis |
AASS KARS ARD1 |
| Lysine degradation |
ACAT1 ALDH2 SUV39H2 SET7
ECHS1 AASS HADH2 HADHA
ARD1 GCDH ALDH1A1 ALDH1B1
LTB4DH BAT8 BBOX1 HADHSC
ALDH3A2 |
| MAPK signaling pathway |
HRAS SHC1 MAPK4 MAPK9
SOS1 GRB2 EGF GRAP2
MAP2K7 |
| Methane metabolism |
CYP39A1 CAT PRDX6 MPO
|
| Methionine metabolism |
DNMT1 CTH MARS AHCYL1
|
| N-Glycan degradation |
AGA |
| N-Glycans biosynthesis |
OGT DPAGT1 FNTB MAN1A2
ALG5 MAN2A2 CTBS |
| Neurodegenerative Disorders |
APOE PSEN2 SOD1 UCHL1
DRPLA |
| Nicotinate and nicotinamide metabolism |
CSNK1G1 NNT NMNAT2 PAK4
TESK2 MTMR2 ULK1 BST1
BCR HIPK2 STK39 CDKL1
AKT2 PRKCD PRKCE CDK5
CDK8 CDK9 CLK3 MAP2K7
|
| Nitrobenzene degradation |
CYP39A1 FTSJ1 |
| Nitrogen metabolism |
CA5A CTH GLUL |
| Nucleotide sugars metabolism |
GALE UGP2 LTB4DH CTBS
|
| O-Glycans biosynthesis |
OGT SIAT4B GALNT3 C1GALT1
|
| One carbon pool by folate |
MTHFD1 FTHFD DHFR |
| Oxidative phosphorylation |
ATP5B ATP5D ATP5J ATP5O
COX10 ATP6V1C1 COX5A COX5B
ATP6V1E1 COX6C COX7B COX7C
SDHA SDHC COX6A1 ATP5C1
PPA2 NDUFA10 NDUFA11 ATP5J2
ATP6V0E ATP6V1A ATP6V1D NDUFAB1
COX7A1 COX7A2 NDUFB10 GRIM19
CYC1 UQCRB QP-C UQCRC1
UQCRC2 NDUFA3 NDUFA6 NDUFA7
NDUFA9 NDUFB3 NDUFB5 NDUFB7
NDUFB8 NDUFB9 NDUFC1 NDUFC2
NDUFS2 NDUFS3 NDUFS4 NDUFS5
NDUFS8 NDUFV1 NDUFV3 DAP13
ATP6V0A2 |
| Parkinson's disease |
MAPK14 UBE1 UCHL1 UBE2L3
|
| Pentose and glucuronate interconversions |
UGT2B7 UGP2 |
| Pentose phosphate pathway |
GPI TALDO1 ALDOA ALDOB
ALDOC H6PD |
| Phenylalanine metabolism |
AOC3 HPD CYP39A1 ARD1
MAOA MAOB PRDX6 MPO
|
| Phenylalanine, tyrosine and tryptophan biosynthesis |
ENO1 |
| Phosphatidylinositol signaling system |
CALM3 MTMR3 PIK3C2G DUSP14
PLCB1 PIK3CB ITPR3 PTPN9
INPP5A ACP1 DGKG DGKZ
PRKCD PRKCE PTEN IMPA2
PTPN11 PTPN13 OCRL |
| Phospholipid degradation |
PLA2G1B PPAP2B |
| Porphyrin and chlorophyll metabolism |
BLVRA UROD PPOX UGT2B7
HMOX2 FECH ALAD |
| Propanoate metabolism |
ACACA ACACB ACAS2 ACAT1
ALDH2 ECHS1 ALDH6A1 ABAT
PCCA LDHA HADHA MLYCD
ALDH1A1 ALDH1B1 SUCLG1 SUCLG2
MUT ALDH3A2 |
| Prostaglandin and leukotriene metabolism |
AKR1C3 PLA2G1B ALOX15B |
| Proteasome |
PSMA7 PSMB1 PSMC2 PSMC3
PSMC5 PSMD2 PSMD3 PSMD11
|
| Protein export |
OXA1L SRP68 |
| Purine metabolism |
ADCY7 ADCY9 POLE POLH
POLM GUK1 NPR1 NPR2
ADK AK1 POLD2 POLD4
PDE8B NME3 NME4 ADSL
PFAS |
| Pyrimidine metabolism |
POLE POLH POLM POLD2
POLD4 DHODH DUT NME3
NME4 TK2 |
| Pyruvate metabolism |
ACACA ACACB ACAS2 ACAT1
ALDH2 DLAT PCK2 LDHA
PDHB PDHX DLD ALDH1A1
ALDH1B1 GRHPR ME1 HAGH
PDHA1 ALDH3A2 MDH1 MDH2
|
| RNA polymerase |
POLR2E POLR2F POLR2L |
| Reductive carboxylate cycle (CO2 fixation) |
ACAS2 ACO1 IDH2 MDH1
MDH2 |
| Riboflavin metabolism |
MTMR2 ACP1 ACP2 |
| Ribosome |
RPS20 |
| Selenoamino acid metabolism |
CTH MARS AHCYL1 FTSJ1
|
| Sphingoglycolipid metabolism |
CSNK1G1 OGT PAK4 TESK2
ULK1 BCR HIPK2 ACADSB
ASAH1 SGPL1 STK39 CDKL1
ARSA AKT2 PRKCD PRKCE
CDK5 CDK8 CDK9 CLK3
MAP2K7 |
| Starch and sucrose metabolism |
CSNK1G1 GPI PAK4 TESK2
HK2 AGL UGT2B7 ULK1
BCR HIPK2 PYGL GBE1
STK39 AMY2B UGP2 CDKL1
AKT2 PRKCD PRKCE CDK5
CDK8 CDK9 CLK3 MAP2K7
|
| Sterol biosynthesis |
GGPS1 HMGCR FDPS CYP39A1
PMVK DHCR7 |
| Streptomycin biosynthesis |
IMPA2 |
| Styrene degradation |
CYP39A1 FAH GSTZ1 |
| Synthesis and degradation of ketone bodies |
ACAT1 BDH |
| Terpenoid biosynthesis |
GGPS1 FDPS |
| Tetrachloroethene degradation |
EPHX1 LTB4DH |
| Tryptophan metabolism |
AOC3 ACAT1 ALDH2 TPH1
CYP2B6 ECHS1 CYP3A7 CYP39A1
HADH2 HADHA MAOA MAOB
CYP4F8 TDO2 GCDH CYP4F11
CYP4F12 ALDH1A1 ALDH1B1 WARS2
HADHSC ALDH3A2 FTSJ1 |
| Tyrosine metabolism |
AOC3 HPD CYP39A1 ADH1B
ADH1C ARD1 MAOA MAOB
ADH4 ADH6 FAH GSTZ1
FTSJ1 |
| Ubiquinone biosynthesis |
CYP39A1 GRIM19 FNTB DAP13
FTSJ1 |
| Ubiquitin mediated proteolysis |
UBE2R2 CUL1 TCEB2 FBXW7
CDC16 WWP2 UBE1 |
| Urea cycle and metabolism of amino groups |
ASS CKB CKMT2 ACY1
|
| Valine, leucine and isoleucine biosynthesis |
PDHB PDHA1 |
| Valine, leucine and isoleucine degradation |
ACAA1 ACADS HIBADH BCKDHA
BCKDHB ALDH2 ECHS1 ALDH6A1
PCCA HADH2 HADHA ARD1
ALDH1A1 ALDH1B1 MCCC2 MUT
HADHSC ALDH3A2 |
| Vitamin B6 metabolism |
MTMR2 PSAT1 |
| beta-Alanine metabolism |
AOC3 ALDH2 ECHS1 ABAT
HADHA MLYCD ALDH1A1 ALDH1B1
ALDH3A2 |
| gamma-Hexachlorocyclohexane degradation |
PON2 CYP2B6 CYP3A7 CYP39A1
CYP26A1 ACP1 ACP2 CYP4F8
CYP4F11 CYP4F12 ALPI |