SVF Genes - GO Biological Process Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Biological Process)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Biological Process)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.42E-16 4 564 1558 2173 7792 6.42E-16
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006955 immune response 1 187 1558 413 7792 4.13E-33
GO:0007165 signal transduction 7 295 1558 1079 7792 1.99E-10
GO:0007154 cell communication 8 237 1558 840 7792 8.08E-10
GO:0050875 cellular physiological process 115 200 1558 899 7792 4.12E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.20E-11 4 386 1558 1456 7792 1.20E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006952 defense response 2 112 1558 253 7792 4.59E-19
GO:0050874 organismal physiological process 6 115 1558 327 7792 4.31E-11
GO:0007166 cell surface receptor linked signal transduction 11 123 1558 389 7792 1.74E-08
GO:0044267 cellular protein metabolism 92 176 1558 779 7792 3.24E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.64E-10 10 297 1558 1086 7792 1.64E-10
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009611 response to wounding 3 78 1558 169 7792 7.93E-15
GO:0009613 response to pest, pathogen or parasite 4 95 1558 226 7792 1.38E-14
GO:0006954 inflammatory response 5 58 1558 125 7792 1.80E-11
GO:0006968 cellular defense response 20 23 1558 48 7792 1.22E-05
GO:0008283 cell proliferation 27 60 1558 201 7792 4.82E-04
GO:0007267 cell-cell signaling 28 52 1558 169 7792 5.14E-04
GO:0050896 response to stimulus 34 57 1558 194 7792 1.01E-03
GO:0006950 response to stress 59 45 1558 165 7792 1.40E-02
GO:0042127 regulation of cell proliferation 69 48 1558 181 7792 1.91E-02
GO:0007186 G-protein coupled receptor protein signaling pathway 116 63 1558 257 7792 4.14E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.87E-10 6 380 1558 1456 7792 1.87E-10
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007155 cell adhesion 19 107 1558 367 7792 1.10E-05
GO:0007264 small GTPase mediated signal transduction 30 54 1558 179 7792 6.87E-04
GO:0009987 cellular process 36 132 1558 522 7792 1.35E-03
GO:0006357 regulation of transcription from RNA polymerase II promoter 55 53 1558 198 7792 1.19E-02
GO:0009059 macromolecule biosynthesis 80 55 1558 214 7792 2.36E-02
GO:0007275 development 97 128 1558 555 7792 3.59E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.63E-09 3 40 1558 80 7792 1.63E-09
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016064 humoral defense mechanism (sensu Vertebrata) 9 39 1558 79 7792 4.17E-09
GO:0019735 antimicrobial humoral response (sensu Vertebrata) 12 32 1558 62 7792 2.64E-08
GO:0019730 antimicrobial humoral response 15 31 1558 61 7792 6.95E-08
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.92E-09 3 25 1558 40 7792 4.92E-09
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030333 antigen processing 10 21 1558 31 7792 1.03E-08
GO:0019882 antigen presentation 16 20 1558 31 7792 8.10E-08
GO:0006776 vitamin A metabolism 83 3 1558 4 7792 2.71E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.19E-08 2 12 1558 13 7792 4.19E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019886 antigen processing, exogenous antigen via MHC class II 14 12 1558 13 7792 4.19E-08
GO:0019884 antigen presentation, exogenous antigen 13 12 1558 13 7792 4.19E-08
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.64E-07 10 101 1558 315 7792 1.64E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042330 taxis 26 28 1558 75 7792 3.61E-04
GO:0006935 chemotaxis 29 28 1558 77 7792 5.92E-04
GO:0006959 humoral immune response 43 12 1558 27 7792 3.39E-03
GO:0015988 energy coupled proton transport, against electrochemical gradient 47 4 1558 5 7792 6.70E-03
GO:0009615 response to virus 52 15 1558 41 7792 1.00E-02
GO:0010033 response to organic substance 62 4 1558 6 7792 1.69E-02
GO:0016049 cell growth 66 24 1558 79 7792 1.81E-02
GO:0042221 response to chemical stimulus 68 39 1558 142 7792 1.88E-02
GO:0050794 regulation of cellular process 78 12 1558 33 7792 2.13E-02
GO:0006477 protein amino acid sulfation 82 3 1558 4 7792 2.71E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.22E-07 6 111 1558 365 7792 8.22E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008219 cell death 25 13 1558 25 7792 3.59E-04
GO:0009607 response to biotic stimulus 35 21 1558 54 7792 1.04E-03
GO:0006915 apoptosis 39 68 1558 245 7792 1.85E-03
GO:0012501 programmed cell death 76 49 1558 186 7792 2.03E-02
GO:0016265 death 89 6 1558 13 7792 2.99E-02
GO:0042060 wound healing 90 17 1558 54 7792 3.04E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.39E-06 2 15 1558 24 7792 6.39E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019885 antigen processing, endogenous antigen via MHC class I 17 15 1558 23 7792 2.94E-06
GO:0019883 antigen presentation, endogenous antigen 18 14 1558 21 7792 4.34E-06
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.20E-05 7 67 1558 206 7792 1.20E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade 42 22 1558 62 7792 3.15E-03
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade 49 20 1558 58 7792 6.86E-03
GO:0007266 Rho protein signal transduction 50 8 1558 16 7792 6.94E-03
GO:0009967 positive regulation of signal transduction 56 21 1558 65 7792 1.28E-02
GO:0045860 positive regulation of protein kinase activity 64 7 1558 15 7792 1.79E-02
GO:0000165 MAPKKK cascade 98 16 1558 51 7792 3.62E-02
GO:0043065 positive regulation of apoptosis 118 22 1558 77 7792 4.45E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.75E-05 4 41 1558 114 7792 4.75E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0051674 localization of cell 22 32 1558 86 7792 1.51E-04
GO:0040011 locomotion 21 32 1558 86 7792 1.51E-04
GO:0006928 cell motility 31 35 1558 104 7792 7.04E-04
GO:0019835 cytolysis 46 6 1558 10 7792 6.33E-03
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.38E-04 4 45 1558 134 7792 1.38E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007229 integrin-mediated signaling pathway 23 19 1558 42 7792 1.83E-04
GO:0030593 neutrophil chemotaxis 87 3 1558 4 7792 2.71E-02
GO:0006916 anti-apoptosis 117 22 1558 77 7792 4.45E-02
GO:0043066 negative regulation of apoptosis 119 25 1558 90 7792 4.63E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.83E-04 5 19 1558 42 7792 1.83E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006956 complement activation 33 11 1558 21 7792 9.51E-04
GO:0045087 innate immune response 51 14 1558 37 7792 9.10E-03
GO:0006958 complement activation, classical pathway 53 8 1558 17 7792 1.08E-02
GO:0006970 response to osmotic stress 103 2 1558 2 7792 4.00E-02
GO:0008228 opsonization 104 2 1558 2 7792 4.00E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.11E-04 4 13 1558 24 7792 2.11E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0051480 cytosolic calcium ion homeostasis 24 10 1558 16 7792 2.43E-04
GO:0007204 elevation of cytosolic calcium ion concentration 32 10 1558 18 7792 8.96E-04
GO:0007202 phospholipase C activation 73 5 1558 9 7792 1.95E-02
GO:0019377 glycolipid catabolism 105 2 1558 2 7792 4.00E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.62E-04 6 14 1558 28 7792 3.62E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0050863 regulation of T cell activation 38 4 1558 4 7792 1.59E-03
GO:0042110 T cell activation 61 8 1558 18 7792 1.61E-02
GO:0015884 folic acid transport 85 3 1558 4 7792 2.71E-02
GO:0046649 lymphocyte activation 99 7 1558 17 7792 3.74E-02
GO:0045576 mast cell activation 109 2 1558 2 7792 4.00E-02
GO:0051249 regulation of lymphocyte activation 111 2 1558 2 7792 4.00E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.65E-04 4 41 1558 126 7792 5.65E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006817 phosphate transport 41 22 1558 62 7792 3.15E-03
GO:0015698 inorganic anion transport 70 29 1558 100 7792 1.93E-02
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway 79 8 1558 19 7792 2.31E-02
GO:0009168 purine ribonucleoside monophosphate biosynthesis 95 4 1558 7 7792 3.32E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.74E-04 3 8 1558 12 7792 5.74E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008064 regulation of actin polymerization and/or depolymerization 44 5 1558 7 7792 4.65E-03
GO:0030833 regulation of actin filament polymerization 96 4 1558 7 7792 3.32E-02
GO:0042572 retinol metabolism 107 2 1558 2 7792 4.00E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.35E-04 5 88 1558 322 7792 7.35E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007167 enzyme linked receptor protein signaling pathway 40 23 1558 65 7792 2.67E-03
GO:0006909 phagocytosis 45 6 1558 10 7792 6.33E-03
GO:0009653 morphogenesis 71 34 1558 121 7792 1.94E-02
GO:0048513 organ development 77 45 1558 169 7792 2.12E-02
GO:0009887 organ morphogenesis 88 22 1558 74 7792 2.92E-02
 
 
 
Cluster 20 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.53E-04 4 30 1558 86 7792 8.53E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042981 regulation of apoptosis 57 24 1558 77 7792 1.31E-02
GO:0043067 regulation of programmed cell death 63 18 1558 55 7792 1.78E-02
GO:0009166 nucleotide catabolism 84 3 1558 4 7792 2.71E-02
GO:0030162 regulation of proteolysis 86 3 1558 4 7792 2.71E-02
 
 
 
Cluster 21 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.94E-04 3 20 1558 50 7792 8.94E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016051 carbohydrate biosynthesis 54 7 1558 14 7792 1.15E-02
GO:0040007 growth 65 13 1558 36 7792 1.79E-02
GO:0008361 regulation of cell size 74 9 1558 22 7792 2.00E-02
 
 
 
Cluster 22 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.94E-04 3 6 1558 11 7792 1.16E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0001516 prostaglandin biosynthesis 37 5 1558 6 7792 1.59E-03
GO:0046457 prostanoid biosynthesis 48 4 1558 5 7792 6.70E-03
GO:0006693 prostaglandin metabolism 93 5 1558 10 7792 3.27E-02
 
 
 
Cluster 23 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.52E-02 3 26 1558 86 7792 1.52E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0051242 positive regulation of cellular physiological process 67 24 1558 79 7792 1.81E-02
GO:0008284 positive regulation of cell proliferation 91 24 1558 83 7792 3.24E-02
GO:0043405 regulation of MAPK activity 108 2 1558 2 7792 4.00E-02
 
 
 
Cluster 24 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.00E-02 2 15 1558 44 7792 2.00E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007160 cell-matrix adhesion 75 15 1558 44 7792 2.00E-02
GO:0031589 cell-substrate adhesion 81 14 1558 41 7792 2.38E-02
 
 
 
Cluster 25 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.27E-02 2 5 1558 10 7792 3.27E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006044 N-acetylglucosamine metabolism 72 5 1558 9 7792 1.95E-02
GO:0006041 glucosamine metabolism 94 4 1558 7 7792 3.32E-02
 
 
 
Cluster 26 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.00E-02 2 2 1558 2 7792 4.00E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0031649 heat generation 106 2 1558 2 7792 4.00E-02
GO:0001660 fever 100 2 1558 2 7792 4.00E-02
 
 
 
Cluster 27 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.00E-02 2 2 1558 2 7792 4.00E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006923 cleavage of cytoskeletal proteins 102 2 1558 2 7792 4.00E-02
GO:0006922 cleavage of lamin 101 2 1558 2 7792 4.00E-02
 
 
 
Cluster 28 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.00E-02 3 2 1558 2 7792 4.00E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0051495 positive regulation of cytoskeleton organization and biogenesis 113 2 1558 2 7792 4.00E-02
GO:0051492 regulation of stress fiber formation 112 2 1558 2 7792 4.00E-02
GO:0051496 positive regulation of stress fiber formation 114 2 1558 2 7792 4.00E-02
 
 
 
Cluster 29 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.00E-02 1 2 1558 2 7792 4.00E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0046131 pyrimidine ribonucleoside metabolism 110 2 1558 2 7792 4.00E-02