SVF Genes - GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

1.53E-15

 12 367 1631 1334 8424 1.53E-15
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005125 cytokine activity 5 48 1631 117 8424 4.62E-08
GO:0046983 protein dimerization activity 10 42 1631 122 8424 5.74E-05
GO:0005057 receptor signaling protein activity 11 25 1631 61 8424 7.84E-05
GO:0005164 tumor necrosis factor receptor binding 15 8 1631 13 8424 9.84E-04
GO:0003735 structural constituent of ribosome 17 37 1631 117 8424 1.01E-03
GO:0005102 receptor binding 19 71 1631 262 8424 1.23E-03
GO:0005198 structural molecule activity 26 105 1631 423 8424 2.71E-03
GO:0043565 sequence-specific DNA binding 27 69 1631 264 8424 3.83E-03
GO:0005178 integrin binding 39 10 1631 24 8424 9.94E-03
GO:0008083 growth factor activity 44 24 1631 80 8424 1.45E-02
GO:0005516 calmodulin binding 49 25 1631 87 8424 2.20E-02
GO:0003712 transcription cofactor activity 75 47 1631 193 8424 4.90E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

7.02E-13

 7 61 1631 130 8424 7.02E-13
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042379 chemokine receptor binding 7 19 1631 34 8424 2.39E-06
GO:0008009 chemokine activity 6 19 1631 34 8424 2.39E-06
GO:0005201 extracellular matrix structural constituent 9 24 1631 52 8424 1.00E-05
GO:0046982 protein heterodimerization activity 40 13 1631 35 8424 1.07E-02
GO:0042287 MHC protein binding 47 5 1631 9 8424 1.70E-02
GO:0008147 structural constituent of bone 53 3 1631 4 8424 2.48E-02
GO:0004850 uridine phosphorylase activity 58 2 1631 2 8424 3.75E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

2.30E-11

 5 859 1631 3819 8424 2.30E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004871 signal transducer activity 1 240 1631 831 8424 1.81E-12
GO:0004872 receptor activity 2 176 1631 608 8424 2.07E-09
GO:0004888 transmembrane receptor activity 3 70 1631 194 8424 2.62E-08
GO:0005515 protein binding 20 526 1631 2458 8424 1.40E-03
GO:0000166 nucleotide binding 25 252 1631 1118 8424 2.49E-03
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

1.59E-10

 3 23 1631 32 8424 1.59E-10
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0045012 MHC class II receptor activity 4 12 1631 13 8424 2.87E-08
GO:0030106 MHC class I receptor activity 8 14 1631 22 8424 6.57E-06
GO:0046582 Rap GTPase activator activity 37 3 1631 3 8424 7.25E-03
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

2.79E-07

 8 73 1631 216 8424 2.79E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005096 GTPase activator activity 12 36 1631 109 8424 4.74E-04
GO:0019865 immunoglobulin binding 16 8 1631 13 8424 9.84E-04
GO:0003823 antigen binding 18 11 1631 22 8424 1.18E-03
GO:0008047 enzyme activator activity 35 35 1631 121 8424 6.90E-03
GO:0001671 ATPase stimulator activity 36 3 1631 3 8424 7.25E-03
GO:0030695 GTPase regulator activity 48 30 1631 108 8424 2.08E-02
GO:0003872 6-phosphofructokinase activity 56 2 1631 2 8424 3.75E-02
GO:0004950 chemokine receptor activity 73 5 1631 11 8424 4.44E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

6.71E-05

 5 7 1631 8 8424 6.71E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004955 prostaglandin receptor activity 52 3 1631 4 8424 2.48E-02
GO:0004954 prostanoid receptor activity 60 2 1631 2 8424 3.75E-02
GO:0004960 thromboxane receptor activity 61 2 1631 2 8424 3.75E-02
GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity 70 2 1631 2 8424 3.75E-02
GO:0004947 bradykinin receptor activity 59 2 1631 2 8424 3.75E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

7.93E-05

 3 27 1631 68 8424 7.93E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005539 glycosaminoglycan binding 22 22 1631 61 8424 1.63E-03
GO:0008201 heparin binding 28 17 1631 46 8424 3.99E-03
GO:0016860 intramolecular oxidoreductase activity 29 5 1631 7 8424 4.01E-03
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

3.05E-04

 3 6 1631 7 8424 3.05E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0045125 bioactive lipid receptor activity 34 4 1631 5 8424 5.92E-03
GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity 32 4 1631 5 8424 5.92E-03
GO:0008511

sodium:potassium:chloride symporter activity

 65 2 1631 2 8424 3.75E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

5.59E-04

 4 67 1631 238 8424 5.59E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019001 guanyl nucleotide binding 14 64 1631 226 8424 6.21E-04
GO:0005525 GTP binding 13 64 1631 226 8424 6.21E-04
GO:0003924 GTPase activity 24 35 1631 114 8424 2.39E-03
GO:0004681 casein kinase I activity 51 3 1631 4 8424 2.48E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

7.02E-04

 4 28 1631 80 8424 7.02E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004866 endopeptidase inhibitor activity 41 22 1631 70 8424 1.07E-02
GO:0019864 IgG binding 45 4 1631 6 8424 1.50E-02
GO:0004867 serine-type endopeptidase inhibitor activity 54 15 1631 48 8424 3.34E-02
GO:0017106 activin inhibitor activity 67 2 1631 2 8424 3.75E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

9.41E-04

 4 14 1631 31 8424 9.41E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005520 insulin-like growth factor binding 31 8 1631 16 8424 5.65E-03
GO:0019838 growth factor binding 50 10 1631 27 8424 2.45E-02
GO:0005094 Rho GDP-dissociation inhibitor activity 62 2 1631 2 8424 3.75E-02
GO:0030019 tryptase activity 68 2 1631 2 8424 3.75E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

3.57E-03

 3 28 1631 88 8424 3.57E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019863 IgE binding 33 4 1631 5 8424 5.92E-03
GO:0005529 sugar binding 43 25 1631 84 8424 1.42E-02
GO:0030246 carbohydrate binding 46 25 1631 85 8424 1.65E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

5.91E-03

 3 29 1631 95 8424 5.91E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004252 serine-type endopeptidase activity 30 26 1631 82 8424 5.13E-03
GO:0008236 serine-type peptidase activity 42 21 1631 66 8424 1.08E-02
GO:0030023 extracellular matrix constituent conferring elasticity 69 2 1631 2 8424 3.75E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

1.65E-02

 2 6 1631 12 8424 1.65E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0001948 glycoprotein binding 55 2 1631 2 8424 3.75E-02
GO:0015026 coreceptor activity 74 5 1631 11 8424 4.44E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

1.92E-02

 2 8 1631 19 8424 1.92E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015288 porin activity 23 8 1631 14 8424 1.91E-03
GO:0015267 channel or pore class transporter activity 38 8 1631 17 8424 8.89E-03
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

3.75E-02

 2 2 1631 2 8424 3.75E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008374 O-acyltransferase activity 64 2 1631 2 8424 3.75E-02
GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity 57 2 1631 2 8424 3.75E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

3.75E-02

 2 2 1631 2 8424 3.75E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 71 2 1631 2 8424 3.75E-02
GO:0005547 phosphatidylinositol-3,4,5-triphosphate binding 63 2 1631 2 8424 3.75E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

3.75E-02

 1 2 1631 2 8424 3.75E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016316

phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity

 66 2 1631 2 8424 3.75E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value

3.98E-02

 2 15 1631 49 8424 3.98E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005021 vascular endothelial growth factor receptor activity 21 7 1631 11 8424 1.60E-03
GO:0004714 transmembrane receptor protein tyrosine kinase activity 72 15 1631 49 8424 3.98E-02