Adipocytes Genes - GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.51E-19 8 57 2183 76 8424 3.51E-19
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016651 oxidoreductase activity, acting on NADH or NADPH 3 29 2183 34 8424 5.73E-13
GO:0003954 NADH dehydrogenase activity 4 27 2183 31 8424 1.31E-12
GO:0000339 RNA cap binding 16 5 2183 5 8424 1.16E-03
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 33 5 2183 7 8424 1.51E-02
GO:0004029 aldehyde dehydrogenase (NAD) activity 44 4 2183 5 8424 1.78E-02
GO:0004300 enoyl-CoA hydratase activity 45 4 2183 5 8424 1.78E-02
GO:0005095 GTPase inhibitor activity 58 5 2183 8 8424 3.17E-02
GO:0003950

NAD+ ADP-ribosyltransferase activity

 69 7 2183 14 8424 4.58E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.33E-18 4 343 2183 890 8424 1.33E-18
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016491 oxidoreductase activity 1 165 2183 343 8424 1.64E-19
GO:0005489 electron transporter activity 2 96 2183 186 8424 3.52E-14
GO:0005215 transporter activity 13 157 2183 461 8424 3.96E-05
GO:0016874 ligase activity 14 62 2183 159 8424 1.80E-04
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.26E-16 7 167 2183 368 8424 1.26E-16
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015399 primary active transporter activity 5 40 2183 57 8424 2.85E-12
GO:0015078 hydrogen ion transporter activity 9 55 2183 96 8424 5.98E-11
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 12 25 2183 44 8424 1.29E-05
GO:0005506 iron ion binding 20 59 2183 164 8424 2.58E-03
GO:0016462 pyrophosphatase activity 21 24 2183 55 8424 3.18E-03
GO:0009055 electron carrier activity 23 7 2183 10 8424 4.35E-03
GO:0008034 lipoprotein binding 65 6 2183 11 8424 4.05E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.35E-11 7 54 2183 91 8424 1.35E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0050136 NADH dehydrogenase (quinone) activity 7 27 2183 32 8424 6.31E-12
GO:0008137 NADH dehydrogenase (ubiquinone) activity 6 27 2183 32 8424 6.31E-12
GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 8 29 2183 36 8424 9.73E-12
GO:0015081 sodium ion transporter activity 10 27 2183 34 8424 9.56E-11
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 53 6 2183 10 8424 2.35E-02
GO:0005159 insulin-like growth factor receptor binding 59 5 2183 8 8424 3.17E-02
GO:0003707 steroid hormone receptor activity 70 14 2183 35 8424 4.77E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.12E-08 6 78 2183 172 8424 2.12E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0050662 coenzyme binding 18 24 2183 52 8424 1.25E-03
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 19 8 2183 11 8424 1.52E-03
GO:0051287 NAD binding 28 9 2183 16 8424 9.53E-03
GO:0008307 structural constituent of muscle 48 11 2183 23 8424 1.93E-02
GO:0003777 microtubule motor activity 54 20 2183 51 8424 2.53E-02
GO:0031267 small GTPase binding 55 15 2183 36 8424 2.83E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.53E-08 2 1307 2183 4622 8424 2.53E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003824 catalytic activity 11 609 2183 1981 8424 1.78E-08
GO:0005488 binding 52 938 2183 3465 8424 2.29E-02
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.19E-07 6 42 2183 80 8424 3.19E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004022 alcohol dehydrogenase activity 15 7 2183 8 8424 4.82E-04
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 30 6 2183 9 8424 1.20E-02
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters 50 8 2183 15 8424 2.14E-02
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 57 5 2183 8 8424 3.17E-02
GO:0019829 cation-transporting ATPase activity 63 16 2183 40 8424 3.56E-02
GO:0046961

hydrogen-transporting ATPase activity, rotational mechanism

 64 13 2183 31 8424 3.78E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.13E-05 4 10 2183 11 8424 1.13E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004886 retinoid-X receptor activity 37 3 2183 3 8424 1.74E-02
GO:0015457 auxiliary transport protein activity 39 3 2183 3 8424 1.74E-02
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 42 3 2183 3 8424 1.74E-02
GO:0003708 retinoic acid receptor activity 43 4 2183 5 8424 1.78E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.07E-05 5 13 2183 18 8424 5.07E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016421 CoA carboxylase activity 17 5 2183 5 8424 1.16E-03
GO:0009374 biotin binding 27 4 2183 4 8424 4.50E-03
GO:0016879 ligase activity, forming carbon-nitrogen bonds 31 6 2183 9 8424 1.20E-02
GO:0004075 biotin carboxylase activity 34 3 2183 3 8424 1.74E-02
GO:0045182 translation regulator activity 68 4 2183 6 8424 4.26E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.93E-04 4 19 2183 34 8424 1.93E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004601 peroxidase activity 22 12 2183 22 8424 3.92E-03
GO:0016209 antioxidant activity 29 12 2183 24 8424 9.65E-03
GO:0016453 C-acetyltransferase activity 40 3 2183 3 8424 1.74E-02
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 49 8 2183 15 8424 2.14E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.82E-04 2 7 2183 8 8424 4.82E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019787 ubiquitin-like-protein ligase activity 41 3 2183 3 8424 1.74E-02
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 46 4 2183 5 8424 1.78E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.19E-04 3 9 2183 12 8424 5.19E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004459 L-lactate dehydrogenase activity 26 4 2183 4 8424 4.50E-03
GO:0004457 lactate dehydrogenase activity 25 4 2183 4 8424 4.50E-03
GO:0042562 hormone binding 62 5 2183 8 8424 3.17E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.28E-03 3 392 2183 1338 8424 1.28E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030554 adenyl nucleotide binding 32 260 2183 894 8424 1.30E-02
GO:0005524 ATP binding 51 251 2183 871 8424 2.23E-02
GO:0005554 molecular function unknown 56 138 2183 464 8424 3.12E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.52E-03 3 8 2183 11 8424 1.52E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004332 fructose-bisphosphate aldolase activity 35 3 2183 3 8424 1.74E-02
GO:0016832 aldehyde-lyase activity 47 4 2183 5 8424 1.78E-02
GO:0005484 SNAP receptor activity 66 4 2183 6 8424 4.26E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.50E-03 2 4 2183 4 8424 4.50E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004448 isocitrate dehydrogenase activity 24 4 2183 4 8424 4.50E-03
GO:0004449 isocitrate dehydrogenase (NAD+) activity 36 3 2183 3 8424 1.74E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.17E-02 2 5 2183 8 8424 3.17E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor 61 5 2183 8 8424 3.17E-02
GO:0008121 ubiquinol-cytochrome-c reductase activity 60 5 2183 8 8424 3.17E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.26E-02 2 4 2183 6 8424 4.26E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008339 MP kinase activity 38 3 2183 3 8424 1.74E-02
GO:0016909 SAP kinase activity 67 4 2183 6 8424 4.26E-02