SVF Genes - GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.36E-19 14 179 1631 503 8424 8.36E-19
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0046983 protein dimerization activity 7 22 1631 54 8424 2.30E-04
GO:0005057 receptor signaling protein activity 8 15 1631 31 8424 2.45E-04
GO:0005164 tumor necrosis factor receptor binding 11 8 1631 13 8424 9.84E-04
GO:0003823 antigen binding 15 8 1631 14 8424 1.91E-03
GO:0008233 peptidase activity 16 29 1631 89 8424 2.05E-03
GO:0004888 transmembrane receptor activity 17 22 1631 62 8424 2.07E-03
GO:0004252 serine-type endopeptidase activity 19 19 1631 53 8424 3.57E-03
GO:0046982 protein heterodimerization activity 29 13 1631 35 8424 1.07E-02
GO:0005516 calmodulin binding 33 25 1631 87 8424 2.20E-02
GO:0004867 serine-type endopeptidase inhibitor activity 35 15 1631 46 8424 2.29E-02
GO:0008147 structural constituent of bone 37 3 1631 4 8424 2.48E-02
GO:0004386 helicase activity 38 13 1631 39 8424 2.76E-02
GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity 51 2 1631 2 8424 3.75E-02
GO:0015026 coreceptor activity 57 5 1631 11 8424 4.44E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.65E-16 7 41 1631 62 8424 9.65E-16
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0045012 MHC class II receptor activity 1 12 1631 13 8424 2.87E-08
GO:0030106 MHC class I receptor activity 4 14 1631 22 8424 6.57E-06
GO:0005021 vascular endothelial growth factor receptor activity 14 7 1631 11 8424 1.60E-03
GO:0005520 insulin-like growth factor binding 22 8 1631 16 8424 5.65E-03
GO:0001948 glycoprotein binding 40 2 1631 2 8424 3.75E-02
GO:0004850 uridine phosphorylase activity 43 2 1631 2 8424 3.75E-02
GO:0030023 extracellular matrix constituent conferring elasticity 54 2 1631 2 8424 3.75E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.34E-14 9 300 1631 1055 8424 1.34E-14
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008009 chemokine activity 3 19 1631 34 8424 2.39E-06
GO:0005201 extracellular matrix structural constituent 5 23 1631 50 8424 1.64E-05
GO:0004871 signal transducer activity 6 60 1631 200 8424 1.73E-04
GO:0015288 porin activity 9 8 1631 12 8424 4.56E-04
GO:0003735 structural constituent of ribosome 12 37 1631 117 8424 1.01E-03
GO:0043565 sequence-specific DNA binding 21 65 1631 247 8424 4.15E-03
GO:0005529 sugar binding 30 25 1631 84 8424 1.42E-02
GO:0004672 protein kinase activity 32 18 1631 56 8424 1.57E-02
GO:0003700 transcription factor activity 58 113 1631 506 8424 4.76E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.96E-10 11 132 1631 411 8424 1.96E-10
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005525 GTP binding 10 64 1631 226 8424 6.21E-04
GO:0003924 GTPase activity 18 35 1631 114 8424 2.39E-03
GO:0008201 heparin binding 20 17 1631 46 8424 3.99E-03
GO:0046582 Rap GTPase activator activity 26 3 1631 3 8424 7.25E-03
GO:0005096 GTPase activator activity 27 26 1631 84 8424 7.28E-03
GO:0005178 integrin binding 28 10 1631 24 8424 9.94E-03
GO:0019864 IgG binding 31 4 1631 6 8424 1.50E-02
GO:0030674 protein binding, bridging 34 7 1631 16 8424 2.24E-02
GO:0003872 6-phosphofructokinase activity 41 2 1631 2 8424 3.75E-02
GO:0017106 activin inhibitor activity 52 2 1631 2 8424 3.75E-02
GO:0005094 Rho GDP-dissociation inhibitor activity 47 2 1631 2 8424 3.75E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.96E-08 2 380 1631 1568 8424 6.96E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004872 receptor activity 2 145 1631 519 8424 6.50E-07
GO:0000166 nucleotide binding 13 252 1631 1106 8424 1.33E-03
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.45E-05 3 8 1631 9 8424 1.45E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019863 IgE binding 24 4 1631 5 8424 5.92E-03
GO:0030019 tryptase activity 53 2 1631 2 8424 3.75E-02
GO:0008511 sodium:potassium:chloride symporter activity 50 2 1631 2 8424 3.75E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.51E-04 2 7 1631 9 8424 2.51E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity 23 4 1631 5 8424 5.92E-03
GO:0004681 casein kinase I activity 36 3 1631 4 8424 2.48E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.71E-04 2 5 1631 5 8424 2.71E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0001671 ATPase stimulator activity 25 3 1631 3 8424 7.25E-03
GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity 42 2 1631 2 8424 3.75E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.40E-03 2 4 1631 4 8424 1.40E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004960 thromboxane receptor activity 45 2 1631 2 8424 3.75E-02
GO:0004947 bradykinin receptor activity 44 2 1631 2 8424 3.75E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.56E-03 2 6 1631 9 8424 2.56E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005355 glucose transporter activity 39 4 1631 7 8424 2.98E-02
GO:0008395 steroid hydroxylase activity 49 2 1631 2 8424 3.75E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.75E-02 2 2 1631 2 8424 3.75E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity 55 2 1631 2 8424 3.75E-02
GO:0005076 receptor signaling protein serine/threonine kinase signaling protein activity 46 2 1631 2 8424 3.75E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.75E-02 2 2 1631 2 8424 3.75E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 56 2 1631 2 8424 3.75E-02
GO:0005547 phosphatidylinositol-3,4,5-triphosphate binding 48 2 1631 2 8424 3.75E-02