Insulin Down-regulated Genes - GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.34E-05 3 3 142 5 9368 3.34E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019967 interleukin-1, Type I, activating binding 20 1 142 1 9368 1.52E-02
GO:0018685 alkane 1-monooxygenase activity 19 1 142 1 9368 1.52E-02
GO:0004800 thyroxine 5'-deiodinase activity 45 1 142 3 9368 4.48E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.28E-04 2 2 142 2 9368 2.28E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity 10 1 142 1 9368 1.52E-02
GO:0001882 nucleoside binding 9 1 142 1 9368 1.52E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.28E-04 2 2 142 2 9368 2.28E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004771 sterol esterase activity 13 1 142 1 9368 1.52E-02
GO:0004230 glutamyl aminopeptidase activity 11 1 142 1 9368 1.52E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.28E-04 2 2 142 2 9368 2.28E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005415 nucleoside:sodium symporter activity 16 1 142 1 9368 1.52E-02
GO:0005223 intracellular cGMP activated cation channel activity 15 1 142 1 9368 1.52E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.28E-04 2 2 142 2 9368 2.28E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043522 leucine zipper domain binding 21 1 142 1 9368 1.52E-02
GO:0016649 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor 18 1 142 1 9368 1.52E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.68E-04 4 12 142 239 9368 2.68E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015370 solute:sodium symporter activity 26 2 142 16 9368 2.38E-02
GO:0042803 protein homodimerization activity 27 3 142 44 9368 2.87E-02
GO:0003777 microtubule motor activity 43 3 142 52 9368 4.40E-02
GO:0005125 cytokine activity 50 5 142 130 9368 4.74E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.04E-04 3 5 142 42 9368 4.04E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008115 sarcosine oxidase activity 17 1 142 1 9368 1.52E-02
GO:0004909 interleukin-1, Type I, activating receptor activity 14 1 142 1 9368 1.52E-02
GO:0019992 diacylglycerol binding 25 3 142 40 9368 2.24E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.78E-04 2 2 142 3 9368 6.78E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0050031 L-pipecolate oxidase activity 22 1 142 1 9368 1.52E-02
GO:0008393 fatty acid (omega-1)-hydroxylase activity 33 1 142 2 9368 3.01E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.34E-03 2 2 142 4 9368 1.34E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005221 intracellular cyclic nucleotide activated cation channel activity 31 1 142 2 9368 3.01E-02
GO:0004246 peptidyl-dipeptidase A activity 28 1 142 2 9368 3.01E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.34E-03 2 2 142 4 9368 1.34E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030275 LRR domain binding 37 1 142 2 9368 3.01E-02
GO:0008241 peptidyl-dipeptidase activity 32 1 142 2 9368 3.01E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.34E-03 2 2 142 4 9368 1.34E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 35 1 142 2 9368 3.01E-02
GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor 34 1 142 2 9368 3.01E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.21E-03 3 2 142 5 9368 2.21E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004585 ornithine carbamoyltransferase activity 12 1 142 1 9368 1.52E-02
GO:0016743 carboxyl- and carbamoyltransferase activity 36 1 142 2 9368 3.01E-02
GO:0005138 interleukin-6 receptor binding 46 1 142 3 9368 4.48E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.76E-03 8 4 142 39 9368 2.76E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015172 acidic amino acid transporter activity 2 2 142 6 9368 3.29E-03
GO:0005313 L-glutamate transporter activity 1 2 142 6 9368 3.29E-03
GO:0005310 dicarboxylic acid transporter activity 3 2 142 7 9368 4.56E-03
GO:0017153 sodium:dicarboxylate symporter activity 4 2 142 7 9368 4.56E-03
GO:0005343 organic acid:sodium symporter activity 6 2 142 10 9368 9.48E-03
GO:0008603 cAMP-dependent protein kinase regulator activity 8 2 142 11 9368 1.15E-02
GO:0015296 anion:cation symporter activity 23 2 142 14 9368 1.84E-02
GO:0015179 L-amino acid transporter activity 24 2 142 15 9368 2.11E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.29E-03 2 2 142 6 9368 3.29E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0045502 dynein binding 48 1 142 3 9368 4.48E-02
GO:0016527 brain-specific angiogenesis inhibitor activity 47 1 142 3 9368 4.48E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.63E-03 5 34 142 1418 9368 3.63E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004672 protein kinase activity 5 12 142 356 9368 7.76E-03
GO:0000166 nucleotide binding 38 27 142 1241 9368 3.20E-02
GO:0015291 porter activity 40 5 142 121 9368 3.66E-02
GO:0004674 protein serine/threonine kinase activity 42 9 142 307 9368 4.36E-02
GO:0003725 double-stranded RNA binding 49 2 142 23 9368 4.69E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.05E-03 2 9 142 206 9368 4.05E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004713 protein-tyrosine kinase activity 39 5 142 118 9368 3.34E-02
GO:0004866 endopeptidase inhibitor activity 44 4 142 88 9368 4.44E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.03E-02 2 3 142 30 9368 1.03E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015171 amino acid transporter activity 7 3 142 30 9368 1.03E-02
GO:0015203 polyamine transporter activity 41 2 142 21 9368 3.97E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.01E-02 1 1 142 2 9368 3.01E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004657

proline dehydrogenase activity

 29 1 142 2 9368 3.01E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.01E-02 1 1 142 2 9368 3.01E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004694

eukaryotic translation initiation factor 2alpha kinase activity

 30 1 142 2 9368 3.01E-02