Insulin Down-regulated Genes - GO Molecular Function Annotation Clusters

Used notations:

"List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes

"List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)

"Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster

"Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)

"P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test

"FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method

Cluster 1	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.28E-04	2	2	142	2	9368	2.28E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	10	1	142	1	9368	1.52E-02
GO:0001882	nucleoside binding	9	1	142	1	9368	1.52E-02
Cluster 2	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.28E-04	2	2	142	2	9368	2.28E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004771	sterol esterase activity	13	1	142	1	9368	1.52E-02
GO:0004230	glutamyl aminopeptidase activity	11	1	142	1	9368	1.52E-02
Cluster 3	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.28E-04	2	2	142	2	9368	2.28E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0005415	nucleoside:sodium symporter activity	16	1	142	1	9368	1.52E-02
GO:0005223	intracellular cGMP activated cation channel activity	15	1	142	1	9368	1.52E-02
Cluster 4	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.28E-04	2	2	142	2	9368	2.28E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0043522	leucine zipper domain binding	21	1	142	1	9368	1.52E-02
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	18	1	142	1	9368	1.52E-02
Cluster 5	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.28E-04	2	2	142	2	9368	2.28E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0050031	L-pipecolate oxidase activity	22	1	142	1	9368	1.52E-02
GO:0019967	interleukin-1, Type I, activating binding	20	1	142	1	9368	1.52E-02
Cluster 6	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.04E-04	3	5	142	42	9368	4.04E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0008115	sarcosine oxidase activity	17	1	142	1	9368	1.52E-02
GO:0004909	interleukin-1, Type I, activating receptor activity	14	1	142	1	9368	1.52E-02
GO:0019992	diacylglycerol binding	25	3	142	40	9368	2.24E-02
Cluster 7	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	6.78E-04	2	2	142	3	9368	6.78E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0018685	alkane 1-monooxygenase activity	19	1	142	1	9368	1.52E-02
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	30	1	142	2	9368	3.01E-02
Cluster 8	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	1.22E-03	3	10	142	208	9368	1.22E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004657	proline dehydrogenase activity	29	1	142	2	9368	3.01E-02
GO:0004713	protein-tyrosine kinase activity	39	5	142	118	9368	3.34E-02
GO:0004866	endopeptidase inhibitor activity	44	4	142	88	9368	4.44E-02
Cluster 9	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	1.34E-03	2	2	142	4	9368	1.34E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0005221	intracellular cyclic nucleotide activated cation channel activity	31	1	142	2	9368	3.01E-02
GO:0004246	peptidyl-dipeptidase A activity	28	1	142	2	9368	3.01E-02
Cluster 10	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	1.34E-03	2	2	142	4	9368	1.34E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0030275	LRR domain binding	37	1	142	2	9368	3.01E-02
GO:0008241	peptidyl-dipeptidase activity	32	1	142	2	9368	3.01E-02
Cluster 11	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.21E-03	3	2	142	5	9368	2.21E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004585	ornithine carbamoyltransferase activity	12	1	142	1	9368	1.52E-02
GO:0016743	carboxyl- and carbamoyltransferase activity	36	1	142	2	9368	3.01E-02
GO:0005138	interleukin-6 receptor binding	46	1	142	3	9368	4.48E-02
Cluster 12	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.21E-03	2	2	142	5	9368	2.21E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	34	1	142	2	9368	3.01E-02
GO:0004800	thyroxine 5'-deiodinase activity	45	1	142	3	9368	4.48E-02
Cluster 13	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.72E-03	3	9	142	194	9368	2.72E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0042803	protein homodimerization activity	27	3	142	44	9368	2.87E-02
GO:0003725	double-stranded RNA binding	49	2	142	23	9368	4.69E-02
GO:0005125	cytokine activity	50	5	142	130	9368	4.74E-02
Cluster 14	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	2.76E-03	8	4	142	39	9368	2.76E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0015172	acidic amino acid transporter activity	2	2	142	6	9368	3.29E-03
GO:0005313	L-glutamate transporter activity	1	2	142	6	9368	3.29E-03
GO:0005310	dicarboxylic acid transporter activity	3	2	142	7	9368	4.56E-03
GO:0017153	sodium:dicarboxylate symporter activity	4	2	142	7	9368	4.56E-03
GO:0005343	organic acid:sodium symporter activity	6	2	142	10	9368	9.48E-03
GO:0008603	cAMP-dependent protein kinase regulator activity	8	2	142	11	9368	1.15E-02
GO:0015296	anion:cation symporter activity	23	2	142	14	9368	1.84E-02
GO:0015179	L-amino acid transporter activity	24	2	142	15	9368	2.11E-02
Cluster 15	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	3.29E-03	2	2	142	6	9368	3.29E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0045502	dynein binding	48	1	142	3	9368	4.48E-02
GO:0016527	brain-specific angiogenesis inhibitor activity	47	1	142	3	9368	4.48E-02
Cluster 16	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	3.61E-03	2	5	142	68	9368	3.61E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0015370	solute:sodium symporter activity	26	2	142	16	9368	2.38E-02
GO:0003777	microtubule motor activity	43	3	142	52	9368	4.40E-02
Cluster 17	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	5.38E-03	4	33	142	1398	9368	5.38E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004672	protein kinase activity	5	12	142	356	9368	7.76E-03
GO:0000166	nucleotide binding	38	27	142	1241	9368	3.20E-02
GO:0015291	porter activity	40	5	142	121	9368	3.66E-02
GO:0004674	protein serine/threonine kinase activity	42	9	142	307	9368	4.36E-02
Cluster 18	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	1.03E-02	2	3	142	30	9368	1.03E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0015171	amino acid transporter activity	7	3	142	30	9368	1.03E-02
GO:0015203	polyamine transporter activity	41	2	142	21	9368	3.97E-02
Cluster 19	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.48E-02	2	1	142	3	9368	4.48E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	35	1	142	2	9368	3.01E-02
GO:0008393	fatty acid (omega-1)-hydroxylase activity	33	1	142	2	9368	3.01E-02