Insulin Up-regulated Genes - GO Biological Process Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Biological Process)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Biological Process)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.93E-12 4 109 701 709 8687 8.93E-12
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006445 regulation of translation 4 16 701 61 8687 1.76E-05
GO:0006512 ubiquitin cycle 10 41 701 286 8687 1.97E-04
GO:0006950 response to stress 12 29 701 184 8687 3.47E-04
GO:0006396 RNA processing 35 27 701 197 8687 4.42E-03
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.50E-09 4 38 701 174 8687 9.50E-09
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019941 modification-dependent protein catabolism 3 22 701 96 8687 5.58E-06
GO:0006511 ubiquitin-dependent protein catabolism 5 22 701 103 8687 1.85E-05
GO:0019538 protein metabolism 37 8 701 34 8687 4.75E-03
GO:0006417 regulation of protein biosynthesis 52 8 701 38 8687 9.62E-03
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.32E-07 4 38 701 195 8687 2.32E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043037 translation 11 14 701 62 8687 3.30E-04
GO:0006936 muscle contraction 40 15 701 92 8687 6.48E-03
GO:0006986 response to unfolded protein 43 8 701 37 8687 8.15E-03
GO:0006941 striated muscle contraction 44 6 701 23 8687 8.29E-03
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.07E-07 3 25 701 103 8687 4.07E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006092 main pathways of carbohydrate metabolism 6 16 701 62 8687 2.20E-05
GO:0006413 translational initiation 21 10 701 41 8687 1.23E-03
GO:0006096 glycolysis 59 7 701 33 8687 1.45E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.43E-07 4 61 701 395 8687 4.43E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007517 muscle development 8 16 701 70 8687 1.08E-04
GO:0006397 mRNA processing 41 22 701 156 8687 6.92E-03
GO:0016071 mRNA metabolism 79 10 701 64 8687 3.12E-02
GO:0006457 protein folding 93 20 701 163 8687 3.85E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.46E-06 2 12 701 32 8687 3.46E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006595 polyamine metabolism 9 4 701 5 8687 1.97E-04
GO:0006446 regulation of translational initiation 18 8 701 27 8687 9.61E-04
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.24E-05 4 28 701 146 8687 1.24E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030384 phosphoinositide metabolism 15 3 701 3 8687 5.23E-04
GO:0008380 RNA splicing 42 10 701 52 8687 7.77E-03
GO:0007010 cytoskeleton organization and biogenesis 72 12 701 78 8687 2.17E-02
GO:0000245 spliceosome assembly 95 4 701 17 8687 4.29E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.75E-05 4 35 701 206 8687 1.75E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0000398 nuclear mRNA splicing, via spliceosome 30 18 701 109 8687 2.62E-03
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 54 15 701 98 8687 1.15E-02
GO:0043412 biopolymer modification 70 12 701 77 8687 1.97E-02
GO:0006937 regulation of muscle contraction 73 5 701 21 8687 2.31E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.64E-05 3 9 701 25 8687 8.64E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009060 aerobic respiration 7 9 701 25 8687 8.64E-05
GO:0006099 tricarboxylic acid cycle 13 7 701 19 8687 4.60E-04
GO:0046356 acetyl-CoA catabolism 14 7 701 19 8687 4.60E-04
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.81E-05 4 117 701 1044 8687 8.81E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009059 macromolecule biosynthesis 1 40 701 215 8687 4.04E-07
GO:0006412 protein biosynthesis 2 39 701 214 8687 9.77E-07
GO:0044267 cellular protein metabolism 23 94 701 869 8687 1.53E-03
GO:0006886 intracellular protein transport 80 22 701 181 8687 3.41E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.06E-04 5 11 701 37 8687 1.06E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030433 ER-associated protein catabolism 20 4 701 7 8687 1.21E-03
GO:0006515 misfolded or incompletely synthesized protein catabolism 19 4 701 7 8687 1.21E-03
GO:0043161 proteasomal ubiquitin-dependent protein catabolism 56 4 701 12 8687 1.23E-02
GO:0006555 methionine metabolism 78 3 701 9 8687 3.04E-02
GO:0043285 biopolymer catabolism 91 4 701 16 8687 3.50E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.10E-04 3 43 701 297 8687 1.10E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006091 generation of precursor metabolites and energy 16 39 701 283 8687 6.25E-04
GO:0006118 electron transport 34 31 701 234 8687 4.03E-03
GO:0006732 coenzyme metabolism 77 4 701 15 8687 2.80E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.47E-04 3 13 701 51 8687 1.47E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0031497 chromatin assembly 25 10 701 43 8687 1.82E-03
GO:0006334 nucleosome assembly 29 10 701 45 8687 2.61E-03
GO:0009068 aspartate family amino acid catabolism 47 3 701 6 8687 8.69E-03
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.64E-04 3 6 701 12 8687 1.64E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006650 glycerophospholipid metabolism 46 3 701 6 8687 8.69E-03
GO:0019369 arachidonic acid metabolism 87 2 701 4 8687 3.50E-02
GO:0030516 regulation of axon extension 88 2 701 4 8687 3.50E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.94E-04 3 12 701 49 8687 3.94E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006100 tricarboxylic acid cycle intermediate metabolism 38 5 701 15 8687 5.11E-03
GO:0015985 energy coupled proton transport, down electrochemical gradient 61 7 701 34 8687 1.70E-02
GO:0006104 succinyl-CoA metabolism 63 2 701 3 8687 1.85E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.53E-04 2 4 701 6 8687 5.53E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043488 regulation of mRNA stability 69 2 701 3 8687 1.85E-02
GO:0019642 anaerobic glycolysis 66 2 701 3 8687 1.85E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.21E-03 2 4 701 7 8687 1.21E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009409 response to cold 65 2 701 3 8687 1.85E-02
GO:0007569 cell aging 85 2 701 4 8687 3.50E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.21E-03 2 4 701 7 8687 1.21E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030032 lamellipodium biogenesis 67 2 701 3 8687 1.85E-02
GO:0007028 cytoplasm organization and biogenesis 84 2 701 4 8687 3.50E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.39E-03 4 34 701 247 8687 1.39E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006631 fatty acid metabolism 22 17 701 94 8687 1.24E-03
GO:0016567 protein ubiquitination 32 9 701 39 8687 3.22E-03
GO:0019752 carboxylic acid metabolism 50 16 701 104 8687 8.83E-03
GO:0044255 cellular lipid metabolism 92 14 701 103 8687 3.66E-02
 
 
 
Cluster 20 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.44E-03 4 9 701 35 8687 1.44E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005977 glycogen metabolism 53 6 701 24 8687 1.03E-02
GO:0006073 glucan metabolism 55 4 701 12 8687 1.23E-02
GO:0006518 peptide metabolism 58 3 701 7 8687 1.43E-02
GO:0006112 energy reserve metabolism 90 4 701 16 8687 3.50E-02
 
 
 
Cluster 21 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.21E-03 2 7 701 24 8687 2.21E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019883 antigen presentation, endogenous antigen 17 7 701 21 8687 9.20E-04
GO:0019885 antigen processing, endogenous antigen via MHC class I 24 7 701 23 8687 1.68E-03
 
 
 
Cluster 22 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.63E-03 2 12 701 60 8687 2.63E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007507 heart development 60 5 701 19 8687 1.51E-02
GO:0006261 DNA-dependent DNA replication 96 7 701 41 8687 4.37E-02
 
 
 
Cluster 23 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.65E-03 2 5 701 14 8687 3.65E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019884 antigen presentation, exogenous antigen 27 5 701 13 8687 2.51E-03
GO:0019886 antigen processing, exogenous antigen via MHC class II 33 5 701 14 8687 3.65E-03
 
 
 
Cluster 24 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.65E-03 2 5 701 14 8687 3.65E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 83 2 701 4 8687 3.50E-02
GO:0051348 negative regulation of transferase activity 94 3 701 10 8687 4.09E-02
 
 
 
Cluster 25 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.12E-03 2 6 701 21 8687 5.12E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 31 6 701 19 8687 2.94E-03
GO:0042775 ATP synthesis coupled electron transport (sensu Eukaryota) 39 6 701 21 8687 5.12E-03
 
 
 
Cluster 26 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.46E-03 2 9 701 42 8687 5.46E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015992 proton transport 36 9 701 41 8687 4.61E-03
GO:0006818 hydrogen transport 57 8 701 40 8687 1.31E-02
 
 
 
Cluster 27 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.86E-03 2 8 701 36 8687 6.86E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019882 antigen presentation 26 8 701 30 8687 2.04E-03
GO:0030333 antigen processing 28 8 701 31 8687 2.56E-03
 
 
 
Cluster 28 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.43E-02 2 3 701 7 8687 1.43E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0050804 regulation of synaptic transmission 49 3 701 6 8687 8.69E-03
GO:0048167 regulation of synaptic plasticity 48 3 701 6 8687 8.69E-03
 
 
 
Cluster 29 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.52E-02 3 8 701 41 8687 1.52E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006119 oxidative phosphorylation 51 8 701 38 8687 9.62E-03
GO:0015986 ATP synthesis coupled proton transport 62 7 701 34 8687 1.70E-02
GO:0006754 ATP biosynthesis 75 7 701 37 8687 2.64E-02
 
 
 
Cluster 30 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.50E-02 3 2 701 4 8687 3.50E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030970 retrograde protein transport, ER to cytosol 68 2 701 3 8687 1.85E-02
GO:0006984 ER-nuclear signaling pathway 64 2 701 3 8687 1.85E-02
GO:0030968 unfolded protein response 89 2 701 4 8687 3.50E-02
 
 
 
Cluster 31 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.50E-02 2 2 701 4 8687 3.50E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006533 aspartate catabolism 82 2 701 4 8687 3.50E-02
GO:0006531 aspartate metabolism 81 2 701 4 8687 3.50E-02
 
 
 
Cluster 32 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.50E-02 1 2 701 4 8687 3.50E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008366 nerve ensheathment 86 2 701 4 8687 3.50E-02