Insulin Up-regulated Genes - GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.52E-09 6 97 738 694 9368 8.52E-09
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015078 hydrogen ion transporter activity 3 25 738 102 9368 2.14E-07
GO:0015399 primary active transporter activity 4 18 738 60 9368 4.37E-07
GO:0005489 electron transporter activity 6 32 738 199 9368 7.67E-05
GO:0003735 structural constituent of ribosome 14 20 738 113 9368 4.72E-04
GO:0005506 iron ion binding 27 25 738 182 9368 4.34E-03
GO:0016491 oxidoreductase activity 30 45 738 386 9368 4.83E-03
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.42E-07 4 459 738 5005 9368 3.42E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003723 RNA binding 1 66 738 421 9368 3.43E-08
GO:0003824 catalytic activity 16 205 738 2154 9368 9.16E-04
GO:0000166 nucleotide binding 28 122 738 1241 9368 4.39E-03
GO:0005515 protein binding 79 240 738 2764 9368 3.45E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.07E-06 6 32 738 163 9368 1.07E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043566 structure-specific DNA binding 5 13 738 41 9368 8.97E-06
GO:0003697 single-stranded DNA binding 12 9 738 29 9368 2.64E-04
GO:0003690 double-stranded DNA binding 22 6 738 19 9368 2.60E-03
GO:0008307 structural constituent of muscle 33 7 738 29 9368 6.15E-03
GO:0003724 RNA helicase activity 40 6 738 24 9368 9.21E-03
GO:0004386 helicase activity 78 12 738 85 9368 3.37E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.31E-06 4 20 738 77 9368 1.31E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008135 translation factor activity, nucleic acid binding 7 16 738 72 9368 1.17E-04
GO:0003743 translation initiation factor activity 18 11 738 50 9368 1.46E-03
GO:0004069 aspartate transaminase activity 34 2 738 2 9368 6.20E-03
GO:0015300 solute:solute antiporter activity 54 2 738 3 9368 1.76E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.87E-06 4 14 738 44 9368 3.87E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0031418 L-ascorbic acid binding 39 4 738 11 9368 8.05E-03
GO:0005080 protein kinase C binding 45 3 738 7 9368 1.34E-02
GO:0008139 nuclear localization sequence binding 59 3 738 8 9368 2.02E-02
GO:0016247 channel regulator activity 87 4 738 18 9368 4.81E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.08E-05 4 50 738 340 9368 1.08E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016874 ligase activity 23 24 738 166 9368 2.63E-03
GO:0016881 acid-amino acid ligase activity 24 18 738 112 9368 2.75E-03
GO:0051082 unfolded protein binding 25 19 738 124 9368 3.69E-03
GO:0004842 ubiquitin-protein ligase activity 37 15 738 94 9368 6.40E-03
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.01E-05 7 19 738 86 9368 3.01E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 20 5 738 13 9368 2.26E-03
GO:0016209 antioxidant activity 38 6 738 23 9368 7.39E-03
GO:0003729 mRNA binding 48 5 738 20 9368 1.71E-02
GO:0042393 histone binding 61 3 738 8 9368 2.02E-02
GO:0004364 glutathione transferase activity 62 4 738 14 9368 2.02E-02
GO:0004601 peroxidase activity 63 5 738 21 9368 2.11E-02
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 64 6 738 29 9368 2.32E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.61E-05 6 45 738 316 9368 6.61E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004298 threonine endopeptidase activity 2 10 738 18 9368 2.12E-07
GO:0030106 MHC class I receptor activity 17 7 738 22 9368 1.09E-03
GO:0045012 MHC class II receptor activity 21 5 738 13 9368 2.26E-03
GO:0016408 C-acyltransferase activity 56 2 738 3 9368 1.76E-02
GO:0004721 phosphoprotein phosphatase activity 68 13 738 94 9368 3.23E-02
GO:0004175 endopeptidase activity 83 22 738 191 9368 4.55E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.29E-05 6 20 738 99 9368 7.29E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030188 chaperone regulator activity 26 3 738 5 9368 4.32E-03
GO:0019829 cation-transporting ATPase activity 32 9 738 43 9368 5.50E-03
GO:0009055 electron carrier activity 43 4 738 12 9368 1.13E-02
GO:0051536 iron-sulfur cluster binding 65 5 738 22 9368 2.56E-02
GO:0051537 2 iron, 2 sulfur cluster binding 67 3 738 9 9368 2.85E-02
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 84 6 738 34 9368 4.72E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.12E-04 6 11 738 38 9368 1.12E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism 53 2 738 3 9368 1.76E-02
GO:0004157 dihydropyrimidinase activity 71 2 738 4 9368 3.34E-02
GO:0004681 casein kinase I activity 73 2 738 4 9368 3.34E-02
GO:0051213 dioxygenase activity 81 4 738 17 9368 3.98E-02
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 89 4 738 18 9368 4.81E-02
GO:0016702

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

 91 5 738 26 9368 4.93E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.04E-04 3 4 738 6 9368 5.04E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005055 laminin receptor activity 36 2 738 2 9368 6.20E-03
GO:0008079 translation termination factor activity 52 2 738 3 9368 1.76E-02
GO:0003747 translation release factor activity 70 2 738 4 9368 3.34E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.10E-03 3 4 738 7 9368 1.10E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004776 succinate-CoA ligase (GDP-forming) activity 35 2 738 2 9368 6.20E-03
GO:0004774 succinate-CoA ligase activity 51 2 738 3 9368 1.76E-02
GO:0005498 sterol carrier activity 74 2 738 4 9368 3.34E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.52E-03 6 10 738 43 9368 1.52E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008137 NADH dehydrogenase (ubiquinone) activity 9 10 738 33 9368 1.51E-04
GO:0003954 NADH dehydrogenase activity 8 10 738 33 9368 1.51E-04
GO:0050136 NADH dehydrogenase (quinone) activity 10 10 738 33 9368 1.51E-04
GO:0015081 sodium ion transporter activity 11 10 738 35 9368 2.59E-04
GO:0016651 oxidoreductase activity, acting on NADH or NADPH 13 10 738 36 9368 3.33E-04
GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 15 10 738 38 9368 5.37E-04
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.86E-03 5 12 738 59 9368 1.86E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0046933 hydrogen-transporting ATP synthase activity, rotational mechanism 41 7 738 32 9368 1.08E-02
GO:0046961 hydrogen-transporting ATPase activity, rotational mechanism 44 7 738 33 9368 1.28E-02
GO:0015405 P-P-bond-hydrolysis-driven transporter activity 47 9 738 51 9368 1.69E-02
GO:0003727 single-stranded RNA binding 57 3 738 8 9368 2.02E-02
GO:0008143 poly(A) binding 75 2 738 4 9368 3.34E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.93E-03 3 7 738 24 9368 1.93E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019888 protein phosphatase regulator activity 49 5 738 20 9368 1.71E-02
GO:0008601 protein phosphatase type 2A regulator activity 69 4 738 16 9368 3.24E-02
GO:0030371 translation repressor activity 77 2 738 4 9368 3.34E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.79E-03 4 12 738 64 9368 3.79E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004843 ubiquitin-specific protease activity 46 9 738 51 9368 1.69E-02
GO:0042809 vitamin D receptor binding 66 3 738 9 9368 2.85E-02
GO:0004221 ubiquitin thiolesterase activity 82 8 738 50 9368 4.01E-02
GO:0016790 thiolester hydrolase activity 90 8 738 52 9368 4.91E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.35E-03 3 11 738 57 9368 4.35E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008426 protein kinase C inhibitor activity 19 3 738 4 9368 1.83E-03
GO:0019904 protein domain specific binding 31 10 738 50 9368 4.94E-03
GO:0005159 insulin-like growth factor receptor binding 80 3 738 10 9368 3.84E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.08E-02 2 29 738 236 9368 1.08E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003779 actin binding 29 25 738 183 9368 4.67E-03
GO:0008092 cytoskeletal protein binding 42 28 738 226 9368 1.09E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.02E-02 2 3 738 8 9368 2.02E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor 60 3 738 8 9368 2.02E-02
GO:0008121 ubiquinol-cytochrome-c reductase activity 58 3 738 8 9368 2.02E-02
 
 
 
Cluster 20 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.34E-02 2 2 738 4 9368 3.34E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004449 isocitrate dehydrogenase (NAD+) activity 50 2 738 3 9368 1.76E-02
GO:0004448 isocitrate dehydrogenase activity 72 2 738 4 9368 3.34E-02
 
 
 
Cluster 21 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.34E-02 2 2 738 4 9368 3.34E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015482 voltage-gated anion channel porin activity 55 2 738 3 9368 1.76E-02
GO:0008308 voltage-gated ion-selective channel activity 76 2 738 4 9368 3.34E-02
 
 
 
Cluster 22 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.81E-02 3 4 738 18 9368 4.81E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015002 heme-copper terminal oxidase activity 86 4 738 18 9368 4.81E-02
GO:0004129 cytochrome-c oxidase activity 85 4 738 18 9368 4.81E-02
GO:0016676 oxidoreductase activity, acting on heme group of donors, oxygen as acceptor 88 4 738 18 9368 4.81E-02