Insulin Down-regulated Genes - GO Biological Process Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Biological Process)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Biological Process)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.16E-12 12 9 129 19 8687 2.16E-12
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006710 androgen catabolism 10 1 129 1 8687 1.48E-02
GO:0006702 androgen biosynthesis 9 1 129 1 8687 1.48E-02
GO:0007616 long-term memory 12 1 129 1 8687 1.48E-02
GO:0046676 negative regulation of insulin secretion 21 1 129 1 8687 1.48E-02
GO:0051310 metaphase plate congression 27 1 129 1 8687 1.48E-02
GO:0007206 metabotropic glutamate receptor, phospholipase C activating pathway 38 1 129 2 8687 2.95E-02
GO:0015858 nucleoside transport 40 1 129 2 8687 2.95E-02
GO:0016925 protein sumoylation 41 1 129 2 8687 2.95E-02
GO:0051382 kinetochore assembly 45 1 129 2 8687 2.95E-02
GO:0006911 phagocytosis, engulfment 53 1 129 3 8687 4.39E-02
GO:0007252 I-kappaB phosphorylation 54 1 129 3 8687 4.39E-02
GO:0016202 regulation of striated muscle development 58 1 129 3 8687 4.39E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.72E-08 24 7 129 23 8687 2.72E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042416 dopamine biosynthesis 15 1 129 1 8687 1.48E-02
GO:0031069 hair follicle morphogenesis 13 1 129 1 8687 1.48E-02
GO:0042637 catagen 16 1 129 1 8687 1.48E-02
GO:0045617 negative regulation of keratinocyte differentiation 18 1 129 1 8687 1.48E-02
GO:0045787 positive regulation of progression through cell cycle 19 1 129 1 8687 1.48E-02
GO:0045823 positive regulation of heart contraction 20 1 129 1 8687 1.48E-02
GO:0048103 somatic stem cell division 22 1 129 1 8687 1.48E-02
GO:0048666 neuron development 23 1 129 1 8687 1.48E-02
GO:0050778 positive regulation of immune response 24 1 129 1 8687 1.48E-02
GO:0050804 regulation of synaptic transmission 25 1 129 1 8687 1.48E-02
GO:0051045 negative regulation of membrane protein ectodomain proteolysis 26 1 129 1 8687 1.48E-02
GO:0051795 positive regulation of catagen 28 1 129 1 8687 1.48E-02
GO:0051891 positive regulation of cardioblast differentiation 29 1 129 1 8687 1.48E-02
GO:0001654 eye development 33 1 129 2 8687 2.95E-02
GO:0001672 regulation of chromatin assembly or disassembly 34 1 129 2 8687 2.95E-02
GO:0001707 mesoderm formation 35 1 129 2 8687 2.95E-02
GO:0010002 cardioblast differentiation 39 1 129 2 8687 2.95E-02
GO:0046653 tetrahydrofolate metabolism 43 1 129 2 8687 2.95E-02
GO:0050777 negative regulation of immune response 44 1 129 2 8687 2.95E-02
GO:0001514 selenocysteine incorporation 50 1 129 3 8687 4.39E-02
GO:0042060 wound healing 59 1 129 3 8687 4.39E-02
GO:0043249 erythrocyte maturation 60 1 129 3 8687 4.39E-02
GO:0043525 positive regulation of neuron apoptosis 61 1 129 3 8687 4.39E-02
GO:0051056 regulation of small GTPase mediated signal transduction 62 1 129 3 8687 4.39E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.13E-05 3 3 129 5 8687 3.13E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0035162 embryonic hemopoiesis 14 1 129 1 8687 1.48E-02
GO:0007136 meiotic prophase II 11 1 129 1 8687 1.48E-02
GO:0016080 synaptic vesicle targeting 57 1 129 3 8687 4.39E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.07E-05 2 5 129 30 8687 7.07E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0048699 neurogenesis 1 2 129 3 8687 6.50E-04
GO:0006865 amino acid transport 6 3 129 27 8687 7.21E-03
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.38E-04 2 3 129 12 8687 6.38E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007088 regulation of mitosis 7 2 129 11 8687 1.10E-02
GO:0001781 neutrophil apoptosis 8 1 129 1 8687 1.48E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.50E-04 2 2 129 3 8687 6.50E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0045079 negative regulation of chemokine biosynthesis 17 1 129 1 8687 1.48E-02
GO:0017157 regulation of exocytosis 42 1 129 2 8687 2.95E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.43E-03 4 24 129 849 8687 1.43E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0051301 cell division 2 7 129 123 8687 2.31E-03
GO:0007049 cell cycle 5 11 129 301 8687 5.06E-03
GO:0006468 protein amino acid phosphorylation 30 12 129 403 8687 1.64E-02
GO:0008283 cell proliferation 49 7 129 218 8687 4.35E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.52E-03 2 4 129 34 8687 1.52E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0000910 cytokinesis 31 2 129 14 8687 1.77E-02
GO:0006953 acute-phase response 46 2 129 20 8687 3.49E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.13E-03 3 2 129 5 8687 2.13E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006562 proline catabolism 37 1 129 2 8687 2.95E-02
GO:0006537 glutamate biosynthesis 36 1 129 2 8687 2.95E-02
GO:0016071 mRNA metabolism 56 1 129 3 8687 4.39E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.97E-03 3 6 129 96 8687 2.97E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015813 L-glutamate transport 4 2 129 7 8687 4.38E-03
GO:0006835 dicarboxylic acid transport 3 2 129 7 8687 4.38E-03
GO:0007283 spermatogenesis 47 4 129 86 8687 3.88E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.02E-03 2 6 129 102 8687 4.02E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016477 cell migration 32 2 129 14 8687 1.77E-02
GO:0008284 positive regulation of cell proliferation 48 4 129 89 8687 4.31E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.39E-02 1 1 129 3 8687 4.39E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016066

cellular defense response (sensu Vertebrata)

 55 1 129 3 8687 4.39E-02