Insulin Up-regulated Genes - GO Biological Process Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Biological Process)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Biological Process)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.92E-13 4 114 701 721 8687 3.92E-13
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006412 protein biosynthesis 1 38 701 205 8687 8.70E-07
GO:0006511 ubiquitin-dependent protein catabolism 2 22 701 96 8687 5.58E-06
GO:0006118 electron transport 15 31 701 233 8687 3.77E-03
GO:0006512 ubiquitin cycle 16 33 701 254 8687 4.16E-03
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.89E-11 7 51 701 236 8687 3.89E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006631 fatty acid metabolism 7 11 701 46 8687 8.49E-04
GO:0006334 nucleosome assembly 11 10 701 43 8687 1.82E-03
GO:0006464 protein modification 25 12 701 72 8687 1.19E-02
GO:0005977 glycogen metabolism 26 4 701 12 8687 1.23E-02
GO:0006104 succinyl-CoA metabolism 30 2 701 3 8687 1.85E-02
GO:0007010 cytoskeleton organization and biogenesis 39 9 701 52 8687 2.19E-02
GO:0006261 DNA-dependent DNA replication 41 3 701 9 8687 3.04E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.49E-09 5 32 701 129 8687 5.49E-09
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006099 tricarboxylic acid cycle 5 7 701 19 8687 4.60E-04
GO:0006446 regulation of translational initiation 9 7 701 23 8687 1.68E-03
GO:0008380 RNA splicing 20 10 701 52 8687 7.77E-03
GO:0016567 protein ubiquitination 21 7 701 30 8687 8.52E-03
GO:0000245 spliceosome assembly 47 3 701 10 8687 4.09E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.64E-08 5 64 701 395 8687 3.64E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007517 muscle development 4 13 701 56 8687 4.01E-04
GO:0006979 response to oxidative stress 22 7 701 31 8687 1.03E-02
GO:0000398 nuclear mRNA splicing, via spliceosome 24 15 701 98 8687 1.15E-02
GO:0006950 response to stress 37 10 701 59 8687 1.86E-02
GO:0006457 protein folding 40 20 701 157 8687 2.72E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.15E-07 4 19 701 66 8687 6.15E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006596 polyamine biosynthesis 6 3 701 3 8687 5.23E-04
GO:0006941 striated muscle contraction 18 5 701 16 8687 6.95E-03
GO:0006445 regulation of translation 19 7 701 29 8687 7.00E-03
GO:0007507 heart development 27 5 701 19 8687 1.51E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.33E-06 4 12 701 31 8687 2.33E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030433 ER-associated protein catabolism 8 4 701 7 8687 1.21E-03
GO:0006533 aspartate catabolism 42 2 701 4 8687 3.50E-02
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 43 2 701 4 8687 3.50E-02
GO:0030163 protein catabolism 45 4 701 16 8687 3.50E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.95E-05 2 9 701 24 8687 5.95E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 13 6 701 19 8687 2.94E-03
GO:0048167 regulation of synaptic plasticity 17 3 701 5 8687 4.62E-03
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.06E-04 3 11 701 37 8687 1.06E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019883 antigen presentation, endogenous antigen 3 7 701 18 8687 3.12E-04
GO:0019885 antigen processing, endogenous antigen via MHC class I 10 7 701 23 8687 1.68E-03
GO:0009966 regulation of signal transduction 38 4 701 14 8687 2.19E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.41E-04 6 22 701 117 8687 1.41E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015992 proton transport 23 8 701 39 8687 1.13E-02
GO:0015986 ATP synthesis coupled proton transport 28 7 701 34 8687 1.70E-02
GO:0030032 lamellipodium biogenesis 34 2 701 3 8687 1.85E-02
GO:0006091 generation of precursor metabolites and energy 46 8 701 49 8687 4.07E-02
GO:0006469 negative regulation of protein kinase activity 48 3 701 10 8687 4.09E-02
GO:0006937 regulation of muscle contraction 49 3 701 10 8687 4.09E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.21E-03 2 4 701 7 8687 1.21E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009409 response to cold 31 2 701 3 8687 1.85E-02
GO:0007569 cell aging 44 2 701 4 8687 3.50E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.65E-03 2 5 701 14 8687 3.65E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019884 antigen presentation, exogenous antigen 12 5 701 13 8687 2.51E-03
GO:0019886 antigen processing, exogenous antigen via MHC class II 14 5 701 14 8687 3.65E-03
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.85E-02 2 2 701 3 8687 1.85E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019642 anaerobic glycolysis 33 2 701 3 8687 1.85E-02
GO:0006100 tricarboxylic acid cycle intermediate metabolism 29 2 701 3 8687 1.85E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.85E-02 2 2 701 3 8687 1.85E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0030970 retrograde protein transport, ER to cytosol 36 2 701 3 8687 1.85E-02
GO:0030968 unfolded protein response 35 2 701 3 8687 1.85E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.85E-02 1 2 701 3 8687 1.85E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019369 arachidonic acid metabolism 32 2 701 3 8687 1.85E-02