Insulin Down-regulated Genes - GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.34E-05 3 3 142 5 9368 3.34E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0050031 L-pipecolate oxidase activity 17 1 142 1 9368 1.52E-02
GO:0018685 alkane 1-monooxygenase activity 14 1 142 1 9368 1.52E-02
GO:0015171 amino acid transporter activity 31 1 142 3 9368 4.48E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.03E-04 4 7 142 72 9368 1.03E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008115 sarcosine oxidase activity 13 1 142 1 9368 1.52E-02
GO:0004909 interleukin-1, Type I, activating receptor activity 10 1 142 1 9368 1.52E-02
GO:0004725 protein tyrosine phosphatase activity 26 3 142 49 9368 3.79E-02
GO:0005279 amino acid-polyamine transporter activity 27 2 142 21 9368 3.97E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.64E-04 3 4 142 19 9368 1.64E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005313 L-glutamate transporter activity 1 2 142 5 9368 2.21E-03
GO:0017153 sodium:dicarboxylate symporter activity 2 2 142 7 9368 4.56E-03
GO:0008603 cAMP-dependent protein kinase regulator activity 3 2 142 11 9368 1.15E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.28E-04 2 2 142 2 9368 2.28E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity 6 1 142 1 9368 1.52E-02
GO:0001882 nucleoside binding 5 1 142 1 9368 1.52E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.28E-04 2 2 142 2 9368 2.28E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004771 sterol esterase activity 9 1 142 1 9368 1.52E-02
GO:0004230 glutamyl aminopeptidase activity 7 1 142 1 9368 1.52E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.28E-04 2 2 142 2 9368 2.28E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005415 nucleoside:sodium symporter activity 12 1 142 1 9368 1.52E-02
GO:0005223 intracellular cGMP activated cation channel activity 11 1 142 1 9368 1.52E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.78E-04 2 2 142 3 9368 6.78E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0043522 leucine zipper domain binding 16 1 142 1 9368 1.52E-02
GO:0004246 peptidyl-dipeptidase A activity 22 1 142 2 9368 3.01E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.34E-03 2 2 142 4 9368 1.34E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004585 ornithine carbamoyltransferase activity 8 1 142 1 9368 1.52E-02
GO:0005138 interleukin-6 receptor binding 30 1 142 3 9368 4.48E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.18E-03 6 34 142 1375 9368 2.18E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005125 cytokine activity 4 4 142 59 9368 1.21E-02
GO:0019992 diacylglycerol binding 18 3 142 40 9368 2.24E-02
GO:0004674 protein serine/threonine kinase activity 19 9 142 284 9368 2.86E-02
GO:0000166 nucleotide binding 20 27 142 1229 9368 2.87E-02
GO:0042803 protein homodimerization activity 21 3 142 44 9368 2.87E-02
GO:0003777 microtubule motor activity 28 3 142 51 9368 4.19E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.21E-03 2 2 142 5 9368 2.21E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008393 fatty acid (omega-1)-hydroxylase activity 25 1 142 2 9368 3.01E-02
GO:0004800 thyroxine 5'-deiodinase activity 29 1 142 3 9368 4.48E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.29E-03 2 2 142 6 9368 3.29E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0045502 dynein binding 33 1 142 3 9368 4.48E-02
GO:0016527 brain-specific angiogenesis inhibitor activity 32 1 142 3 9368 4.48E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.52E-02 1 1 142 1 9368 1.52E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042287

MHC protein binding

 15 1 142 1 9368 1.52E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.01E-02 1 1 142 2 9368 3.01E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004657

proline dehydrogenase activity

 23 1 142 2 9368 3.01E-02