Insulin Up-regulated Genes - GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
7.67E-10 5 83 738 534 9368 7.67E-10
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003697 single-stranded DNA binding 5 9 738 28 9368 1.96E-04
GO:0016874 ligase activity 14 24 738 166 9368 2.63E-03
GO:0051082 unfolded protein binding 16 19 738 124 9368 3.69E-03
GO:0005506 iron ion binding 20 24 738 173 9368 4.53E-03
GO:0004221 ubiquitin thiolesterase activity 51 8 738 49 9368 3.61E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.17E-08 4 88 738 612 9368 1.17E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004298 threonine endopeptidase activity 2 10 738 18 9368 2.12E-07
GO:0016491 oxidoreductase activity 17 40 738 330 9368 3.94E-03
GO:0003779 actin binding 18 24 738 172 9368 4.20E-03
GO:0004842 ubiquitin-protein ligase activity 25 15 738 94 9368 6.40E-03
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.25E-08 5 18 738 49 9368 1.25E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019904 protein domain specific binding 6 5 738 9 9368 2.88E-04
GO:0030106 MHC class I receptor activity 8 7 738 22 9368 1.09E-03
GO:0045012 MHC class II receptor activity 13 5 738 13 9368 2.26E-03
GO:0008121 ubiquinol-cytochrome-c reductase activity 36 3 738 8 9368 2.02E-02
GO:0005246 calcium channel regulator activity 47 2 738 4 9368 3.34E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.62E-08 6 60 738 377 9368 8.62E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003735 structural constituent of ribosome 7 20 738 113 9368 4.72E-04
GO:0003690 double-stranded DNA binding 11 6 738 18 9368 1.91E-03
GO:0031418 L-ascorbic acid binding 26 4 738 11 9368 8.05E-03
GO:0005489 electron transporter activity 40 19 738 148 9368 2.32E-02
GO:0016829 lyase activity 54 11 738 79 9368 4.46E-02
GO:0004129 cytochrome-c oxidase activity 55 4 738 18 9368 4.81E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.44E-07 5 20 738 68 9368 1.44E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008137 NADH dehydrogenase (ubiquinone) activity 4 10 738 33 9368 1.51E-04
GO:0003954 NADH dehydrogenase activity 3 10 738 33 9368 1.51E-04
GO:0042393 histone binding 38 3 738 8 9368 2.02E-02
GO:0042809 vitamin D receptor binding 42 3 738 9 9368 2.85E-02
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 53 4 738 17 9368 3.98E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.46E-07 5 29 738 128 9368 1.46E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003743 translation initiation factor activity 9 11 738 50 9368 1.46E-03
GO:0008307 structural constituent of muscle 21 7 738 29 9368 6.15E-03
GO:0046933 hydrogen-transporting ATP synthase activity, rotational mechanism 28 7 738 32 9368 1.08E-02
GO:0046961 hydrogen-transporting ATPase activity, rotational mechanism 30 7 738 33 9368 1.28E-02
GO:0008601 protein phosphatase type 2A regulator activity 44 4 738 16 9368 3.24E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.58E-06 3 8 738 15 9368 5.58E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003724 RNA helicase activity 15 4 738 9 9368 3.49E-03
GO:0004069 aspartate transaminase activity 22 2 738 2 9368 6.20E-03
GO:0004157 dihydropyrimidinase activity 45 2 738 4 9368 3.34E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.06E-05 3 8 738 18 9368 3.06E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005080 protein kinase C binding 31 3 738 7 9368 1.34E-02
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism 34 2 738 3 9368 1.76E-02
GO:0008139 nuclear localization sequence binding 37 3 738 8 9368 2.02E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.20E-05 3 189 738 1851 9368 3.20E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003723 RNA binding 1 57 738 347 9368 6.04E-08
GO:0000166 nucleotide binding 19 121 738 1229 9368 4.34E-03
GO:0016787 hydrolase activity 27 64 738 605 9368 8.49E-03
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.08E-05 3 10 738 30 9368 6.08E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004601 peroxidase activity 12 5 738 13 9368 2.26E-03
GO:0004364 glutathione transferase activity 39 4 738 14 9368 2.02E-02
GO:0008143 poly(A) binding 49 2 738 4 9368 3.34E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.72E-05 3 7 738 15 9368 6.72E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004776 succinate-CoA ligase (GDP-forming) activity 23 2 738 2 9368 6.20E-03
GO:0008236 serine-type peptidase activity 41 3 738 9 9368 2.85E-02
GO:0005498 sterol carrier activity 48 2 738 4 9368 3.34E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.79E-04 2 4 738 5 9368 1.79E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005055 laminin receptor activity 24 2 738 2 9368 6.20E-03
GO:0003747 translation release factor activity 32 2 738 3 9368 1.76E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.31E-04 3 6 738 15 9368 6.31E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008426 protein kinase C inhibitor activity 10 3 738 4 9368 1.83E-03
GO:0004449 isocitrate dehydrogenase (NAD+) activity 33 2 738 3 9368 1.76E-02
GO:0005159 insulin-like growth factor receptor binding 52 3 738 10 9368 3.84E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.09E-03 3 7 738 22 9368 1.09E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009055 electron carrier activity 29 4 738 12 9368 1.13E-02
GO:0051537 2 iron, 2 sulfur cluster binding 43 3 738 9 9368 2.85E-02
GO:0004681 casein kinase I activity 46 2 738 4 9368 3.34E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.34E-02 2 2 738 4 9368 3.34E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015482 voltage-gated anion channel porin activity 35 2 738 3 9368 1.76E-02
GO:0008308 voltage-gated ion-selective channel activity 50 2 738 4 9368 3.34E-02