Insulin Down-regulated Genes - GO Biological Process Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Biological Process)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Biological Process)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.36E-04 15 36 110 1268 7279 6.43E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015813 L-glutamate transport 1 2 110 5 7279 2.20E-03
GO:0015800 acidic amino acid transport 2 2 110 6 7279 3.26E-03
GO:0015807 L-amino acid transport 3 2 110 7 7279 4.52E-03
GO:0046942 carboxylic acid transport 4 4 110 45 7279 4.57E-03
GO:0008283 cell proliferation 5 12 110 341 7279 5.17E-03
GO:0006835 dicarboxylic acid transport 6 2 110 8 7279 5.97E-03
GO:0007067 mitosis 8 5 110 82 7279 7.81E-03
GO:0046676 negative regulation of insulin secretion 21 1 110 1 7279 1.51E-02
GO:0050796 regulation of insulin secretion 22 1 110 1 7279 1.51E-02
GO:0006953 acute-phase response 23 2 110 16 7279 2.37E-02
GO:0000910 cytokinesis 26 4 110 77 7279 2.88E-02
GO:0006955 immune response 34 10 110 336 7279 3.01E-02
GO:0008151 cell growth and/or maintenance 35 17 110 698 7279 3.21E-02
GO:0015711 organic anion transport 36 2 110 19 7279 3.27E-02
GO:0007049 cell cycle 37 8 110 251 7279 3.58E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.47E-03 2 2 110 2 7279 2.26E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007616 long-term memory 16 1 110 1 7279 1.51E-02
GO:0007206 metabotropic glutamate receptor\, phospholipase C activating pathway 15 1 110 1 7279 1.51E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.62E-03 3 3 110 10 7279 3.73E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009084 glutamine family amino acid biosynthesis 7 2 110 8 7279 5.97E-03
GO:0006537 glutamate biosynthesis 28 1 110 2 7279 3.00E-02
GO:0030180 solute\:solute exchange 32 1 110 2 7279 3.00E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.46E-03 3 2 110 4 7279 1.33E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006710 androgen catabolism 12 1 110 1 7279 1.51E-02
GO:0006702 androgen biosynthesis 11 1 110 1 7279 1.51E-02
GO:0015701 bicarbonate transport 40 1 110 3 7279 4.47E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.46E-03 2 2 110 4 7279 1.33E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0046653 tetrahydrofolate metabolism 20 1 110 1 7279 1.51E-02
GO:0007158 neuronal cell adhesion 39 1 110 3 7279 4.47E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.76E-03 2 2 110 5 7279 2.20E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0001672 regulation of chromatin assembly/disassembly 27 1 110 2 7279 3.00E-02
GO:0043039 tRNA aminoacylation 41 1 110 3 7279 4.47E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.07E-03 2 3 110 19 7279 2.73E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007088 regulation of mitosis 24 2 110 17 7279 2.65E-02
GO:0007613 memory 30 1 110 2 7279 3.00E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.96E-02 2 1 110 1 7279 1.51E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0007136 meiotic prophase II 14 1 110 1 7279 1.51E-02
GO:0007135 meiosis II 13 1 110 1 7279 1.51E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.96E-02 2 1 110 1 7279 1.51E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015931 nucleobase\, nucleoside\, nucleotide and nucleic acid transport 18 1 110 1 7279 1.51E-02
GO:0015858 nucleoside transport 17 1 110 1 7279 1.51E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.96E-02 1 1 110 1 7279 1.51E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016925 protein sumoylation 19 1 110 1 7279 1.51E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.47E-02 3 16 110 660 7279 3.87E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006468 protein amino acid phosphorylation 9 12 110 371 7279 9.90E-03
GO:0016310 phosphorylation 10 12 110 374 7279 1.05E-02
GO:0006464 protein modification 25 16 110 635 7279 2.84E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.47E-02 2 1 110 3 7279 4.47E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006562 proline catabolism 29 1 110 2 7279 3.00E-02
GO:0006536 glutamate metabolism 38 1 110 3 7279 4.47E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.47E-02 2 1 110 3 7279 4.47E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042447 hormone catabolism 33 1 110 2 7279 3.00E-02
GO:0008209 androgen metabolism 31 1 110 2 7279 3.00E-02