Insulin Up-regulated Genes - GO Biological Process Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Biological Process)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Biological Process)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.41E-09 8 106 565 739 7279 7.41E-11
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006412 protein biosynthesis 1 34 565 177 7279 5.44E-07
GO:0009059 macromolecule biosynthesis 4 30 565 173 7279 2.14E-05
GO:0006396 RNA processing 7 26 565 154 7279 1.19E-04
GO:0019538 protein metabolism 8 54 565 424 7279 1.61E-04
GO:0006950 response to stress 14 20 565 125 7279 1.42E-03
GO:0043037 translation 19 11 565 54 7279 2.47E-03
GO:0007519 myogenesis 28 4 565 12 7279 1.07E-02
GO:0007528 neuromuscular junction development 39 2 565 3 7279 1.71E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.79E-08 5 38 565 174 7279 2.94E-09
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019941 modification-dependent protein catabolism 2 21 565 86 7279 1.61E-06
GO:0006511 ubiquitin-dependent protein catabolism 3 21 565 90 7279 3.54E-06
GO:0006261 DNA dependent DNA replication 27 8 565 40 7279 1.05E-02
GO:0009395 phospholipid catabolism 58 2 565 4 7279 3.25E-02
GO:0016071 mRNA metabolism 66 7 565 41 7279 3.64E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.94E-07 9 27 565 108 7279 3.06E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006092 main pathways of carbohydrate metabolism 5 12 565 39 7279 2.37E-05
GO:0006099 tricarboxylic acid cycle 9 6 565 14 7279 3.73E-04
GO:0006007 glucose catabolism 18 7 565 25 7279 2.28E-03
GO:0006096 glycolysis 22 6 565 20 7279 3.22E-03
GO:0006104 succinyl-CoA metabolism 25 2 565 2 7279 6.02E-03
GO:0006100 TCA intermediate metabolism 32 3 565 7 7279 1.28E-02
GO:0016070 RNA metabolism 41 9 565 52 7279 1.74E-02
GO:0009057 macromolecule catabolism 43 4 565 14 7279 1.92E-02
GO:0006613 cotranslational membrane targeting 44 3 565 8 7279 1.94E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.90E-06 5 31 565 159 7279 1.24E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006936 muscle contraction 12 14 565 70 7279 8.11E-04
GO:0007517 muscle development 16 15 565 84 7279 1.81E-03
GO:0006941 striated muscle contraction 23 6 565 21 7279 4.21E-03
GO:0006637 acyl-CoA metabolism 38 2 565 3 7279 1.71E-02
GO:0006367 transcription initiation from Pol II promoter 67 5 565 25 7279 4.01E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
9.02E-06 2 22 565 95 7279 2.37E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006445 regulation of translation 6 14 565 52 7279 2.73E-05
GO:0008380 RNA splicing 20 10 565 47 7279 2.74E-03
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.51E-05 6 53 565 365 7279 4.77E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006631 fatty acid metabolism 17 13 565 68 7279 1.90E-03
GO:0006732 coenzyme metabolism 21 5 565 14 7279 3.07E-03
GO:0019752 carboxylic acid metabolism 31 13 565 84 7279 1.21E-02
GO:0007160 cell-matrix adhesion 49 8 565 47 7279 2.66E-02
GO:0006118 electron transport 68 22 565 192 7279 4.12E-02
GO:0008154 actin polymerization and/or depolymerization 70 3 565 11 7279 4.80E-02
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.00E-04 3 27 565 163 7279 1.24E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006512 ubiquitin cycle 24 13 565 76 7279 5.23E-03
GO:0009607 response to biotic stimulus 26 14 565 86 7279 6.04E-03
GO:0016567 protein ubiquitination 55 4 565 16 7279 3.08E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.00E-04 3 9 565 27 7279 1.26E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019882 antigen presentation 11 7 565 20 7279 5.18E-04
GO:0030333 antigen processing 13 7 565 22 7279 9.94E-04
GO:0006098 pentose-phosphate shunt 56 2 565 4 7279 3.25E-02
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.34E-04 4 11 565 41 7279 2.06E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0009068 aspartate family amino acid catabolism 40 2 565 3 7279 1.71E-02
GO:0006937 regulation of muscle contraction 42 4 565 14 7279 1.92E-02
GO:0007257 activation of JUNK 57 2 565 4 7279 3.25E-02
GO:0007254 JNK cascade 65 5 565 24 7279 3.42E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
8.98E-04 2 10 565 38 7279 4.72E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006413 translational initiation 10 10 565 38 7279 4.72E-04
GO:0006446 regulation of translational initiation 15 7 565 24 7279 1.76E-03
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.17E-03 3 6 565 17 7279 1.25E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006119 oxidative phosphorylation 33 3 565 7 7279 1.28E-02
GO:0019883 antigen presentation\, endogenous antigen 50 3 565 9 7279 2.74E-02
GO:0019885 antigen processing\, endogenous antigen via MHC class I 51 3 565 9 7279 2.74E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
5.83E-03 3 7 565 27 7279 3.68E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006614 SRP-dependent cotranslational membrane targeting 37 2 565 3 7279 1.71E-02
GO:0009889 regulation of biosynthesis 47 4 565 15 7279 2.46E-02
GO:0006417 regulation of protein biosynthesis 53 5 565 23 7279 2.89E-02
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.46E-02 3 5 565 18 7279 1.01E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019932 second-messenger-mediated signaling 34 4 565 13 7279 1.46E-02
GO:0006672 ceramide metabolism 45 3 565 8 7279 1.94E-02
GO:0046519 sphingoid metabolism 52 3 565 9 7279 2.74E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.46E-02 2 4 565 12 7279 1.07E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0019886 antigen processing\, exogenous antigen via MHC class II 30 4 565 12 7279 1.07E-02
GO:0019884 antigen presentation\, exogenous antigen 29 4 565 12 7279 1.07E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.62E-02 3 15 565 109 7279 2.07E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006397 mRNA processing 46 14 565 101 7279 2.35E-02
GO:0000377 RNA splicing\, via transesterification reactions with bulged adenosine as nucleophile 54 9 565 57 7279 3.02E-02
GO:0000398 nuclear mRNA splicing\, via spliceosome 64 10 565 67 7279 3.27E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.18E-02 2 7 565 39 7279 2.85E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0006979 response to oxidative stress 35 6 565 27 7279 1.54E-02
GO:0006800 oxygen and reactive oxygen species metabolism 36 7 565 35 7279 1.63E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.18E-02 2 7 565 39 7279 2.85E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015992 proton transport 48 7 565 38 7279 2.50E-02
GO:0006818 hydrogen transport 69 6 565 34 7279 4.44E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.25E-02 2 2 565 4 7279 3.25E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015986 ATP synthesis coupled proton transport 60 2 565 4 7279 3.25E-02
GO:0015985 energy coupled proton transport\, down electrochemical gradient 59 2 565 4 7279 3.25E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.25E-02 3 2 565 4 7279 3.25E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein 62 2 565 4 7279 3.25E-02
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein 61 2 565 4 7279 3.25E-02
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 63 2 565 4 7279 3.25E-02