Insulin Down-regulated Genes - GO Molecular Function Annotation Clusters

Used notations:

"List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes

"List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)

"Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster

"Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)

"P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test

"FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method

Cluster 1	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	6.12E-07	20	22	116	383	7696	4.37E-08
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0005313	L-glutamate transporter activity	2	2	116	6	7696	3.25E-03
GO:0005310	dicarboxylic acid transporter activity	3	2	116	7	7696	4.50E-03
GO:0015172	acidic amino acid transporter activity	4	2	116	7	7696	4.50E-03
GO:0017153	sodium\:dicarboxylate symporter activity	5	2	116	7	7696	4.50E-03
GO:0015296	anion\:cation symporter activity	6	2	116	8	7696	5.94E-03
GO:0008603	cAMP-dependent protein kinase regulator activity	7	2	116	10	7696	9.37E-03
GO:0008083	growth factor activity	8	5	116	93	7696	1.30E-02
GO:0004230	glutamyl aminopeptidase activity	9	1	116	1	7696	1.51E-02
GO:0004771	sterol esterase activity	11	1	116	1	7696	1.51E-02
GO:0015179	L-amino acid transporter activity	19	2	116	13	7696	1.58E-02
GO:0015291	porter activity	22	5	116	109	7696	2.41E-02
GO:0004866	endopeptidase inhibitor activity	23	4	116	77	7696	2.86E-02
GO:0005125	cytokine activity	24	5	116	115	7696	2.95E-02
GO:0004246	peptidyl-dipeptidase A activity	25	1	116	2	7696	2.99E-02
GO:0008241	peptidyl-dipeptidase activity	29	1	116	2	7696	2.99E-02
GO:0016527	brain-specific angiogenesis inhibitor activity	34	1	116	2	7696	2.99E-02
GO:0015293	symporter activity	38	3	116	48	7696	3.53E-02
GO:0015370	solute\:sodium symporter activity	39	2	116	20	7696	3.59E-02
GO:0019887	protein kinase regulator activity	40	2	116	20	7696	3.59E-02
GO:0015198	oligopeptide transporter activity	44	1	116	3	7696	4.45E-02
Cluster 2	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	3.12E-03	4	15	116	377	7696	5.03E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004672	protein kinase activity	1	12	116	317	7696	2.85E-03
GO:0016705	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen	20	2	116	15	7696	2.08E-02
GO:0004674	protein serine/threonine kinase activity	21	9	116	275	7696	2.27E-02
GO:0003725	double-stranded RNA binding	48	2	116	23	7696	4.64E-02
Cluster 3	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	3.12E-03	2	2	116	3	7696	6.69E-04
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0018685	alkane 1-monooxygenase activity	16	1	116	1	7696	1.51E-02
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	27	1	116	2	7696	2.99E-02
Cluster 4	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.64E-03	4	2	116	4	7696	1.33E-03
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0019967	interleukin-1\, Type I\, activating binding	17	1	116	1	7696	1.51E-02
GO:0004909	interleukin-1\, Type I\, activating receptor activity	12	1	116	1	7696	1.51E-02
GO:0004800	thyroxine 5'-deiodinase activity	42	1	116	3	7696	4.45E-02
GO:0016739	oxidoreductase activity\, acting on other substrates	46	1	116	3	7696	4.45E-02
Cluster 5	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.19E-02	3	1	116	1	7696	1.51E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0016647	oxidoreductase activity\, acting on the CH-NH group of donors\, oxygen as acceptor	15	1	116	1	7696	1.51E-02
GO:0008115	sarcosine oxidase activity	14	1	116	1	7696	1.51E-02
GO:0050031	L-pipecolate oxidase activity	18	1	116	1	7696	1.51E-02
Cluster 6	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.19E-02	2	1	116	2	7696	2.99E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004585	ornithine carbamoyltransferase activity	10	1	116	1	7696	1.51E-02
GO:0016743	carboxyl- and carbamoyltransferase activity	36	1	116	2	7696	2.99E-02
Cluster 7	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.19E-02	2	1	116	2	7696	2.99E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0016876	ligase activity\, forming aminoacyl-tRNA and related compounds	37	1	116	2	7696	2.99E-02
GO:0008452	RNA ligase activity	31	1	116	2	7696	2.99E-02
Cluster 8	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.19E-02	1	1	116	2	7696	2.99E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004657	proline dehydrogenase activity	26	1	116	2	7696	2.99E-02
Cluster 9	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.19E-02	1	1	116	2	7696	2.99E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0005138	interleukin-6 receptor binding	28	1	116	2	7696	2.99E-02
Cluster 10	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	4.19E-02	1	1	116	2	7696	2.99E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0008898	homocysteine S-methyltransferase activity	32	1	116	2	7696	2.99E-02
Cluster 11	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	5.09E-02	2	1	116	3	7696	4.45E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0016713	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, reduced iron-sulfur protein as one donor\, and incorporation of one atom of oxygen	35	1	116	2	7696	2.99E-02
GO:0008393	fatty acid (omega-1)-hydroxylase activity	30	1	116	2	7696	2.99E-02
Cluster 12	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	5.09E-02	1	1	116	3	7696	4.45E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0004718	Janus kinase activity	41	1	116	3	7696	4.45E-02
Cluster 13	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	5.09E-02	2	18	116	788	7696	4.73E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0005524	ATP binding	47	18	116	785	7696	4.58E-02
GO:0030554	adenyl nucleotide binding	49	18	116	788	7696	4.73E-02
Cluster 14	FDR (q-value)	Terms	List Hits	List Total	Population Hits	Population Total	P-value
	5.90E-02	4	1	116	4	7696	5.90E-02
ID	Term	Rank	List Hits	List Total	Population Hits	Population Total	P-values
GO:0005415	nucleoside\:sodium symporter activity	13	1	116	1	7696	1.51E-02
GO:0015294	solute\:cation symporter activity	33	1	116	2	7696	2.99E-02
GO:0005337	nucleoside transporter activity	43	1	116	3	7696	4.45E-02
GO:0015932	nucleobase\, nucleoside\, nucleotide and nucleic acid transporter activity	45	1	116	3	7696	4.45E-02