Insulin Up-regulated Genes - GO Molecular Function Annotation Clusters
 
Used notations:
 
  • "List Hits" - the number of genes annotated by the considered GO category or annotation cluster within the analyzed list of target genes
  • "List Total" - the number of genes within the analyzed list of target genes having at least one GO annotation (Molecular Function)
  • "Population Hits" - the number of genes, available on the entire microarray, annotated by the considered GO category or annotation cluster
  • "Population Total" - the number of genes available on the entire microarray and having at least one GO annotation (Molecular Function)
  • "P-value" - the significance p-value of the gene enrichment of the considered GO category or annotation cluster, calculated with a unilateral Fisher exact test
  • "FDR (q-value)" - the estimated value of the false discovery rate (FDR) by using the Benjamini & Hochberg (2001) method
 
 
Cluster 1 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.76E-08 5 25 580 86 7696 1.98E-09
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015078 hydrogen ion transporter activity 2 20 580 73 7696 2.45E-07
GO:0015399 primary active transporter activity 3 14 580 45 7696 3.04E-06
GO:0030106 MHC class I receptor activity 44 3 580 8 7696 1.79E-02
GO:0008553 hydrogen-exporting ATPase activity\, phosphorylative mechanism 51 3 580 9 7696 2.54E-02
GO:0045182 translation regulator activity 67 2 580 5 7696 4.87E-02
 
 
 
Cluster 2 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.10E-07 6 239 580 2380 7696 3.26E-08
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003723 RNA binding 1 57 580 310 7696 1.29E-10
GO:0005489 electron transporter activity 9 21 580 147 7696 3.21E-03
GO:0016491 oxidoreductase activity 33 33 580 292 7696 1.19E-02
GO:0003824 catalytic activity 63 161 580 1901 7696 4.34E-02
GO:0003702 RNA polymerase II transcription factor activity 65 16 580 135 7696 4.65E-02
GO:0008191 metalloendopeptidase inhibitor activity 66 2 580 5 7696 4.87E-02
 
 
 
Cluster 3 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.95E-06 7 45 580 278 7696 6.23E-07
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016881 acid-D-amino acid ligase activity 7 14 580 81 7696 2.66E-03
GO:0004842 ubiquitin-protein ligase activity 12 12 580 67 7696 3.88E-03
GO:0003789 actin filament severing activity 16 2 580 2 7696 5.67E-03
GO:0016874 ligase activity 29 16 580 112 7696 9.44E-03
GO:0003690 double-stranded DNA binding 30 4 580 12 7696 9.69E-03
GO:0003754 chaperone activity 35 16 580 117 7696 1.41E-02
GO:0005246 calcium channel regulator activity 57 2 580 4 7696 3.07E-02
 
 
 
Cluster 4 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.98E-05 5 18 580 72 7696 4.16E-06
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004840 ubiquitin conjugating enzyme activity 10 9 580 42 7696 3.46E-03
GO:0008639 small protein conjugating enzyme activity 13 9 580 43 7696 4.08E-03
GO:0003727 single-stranded RNA binding 42 3 580 8 7696 1.79E-02
GO:0004157 dihydropyrimidinase activity 55 2 580 4 7696 3.07E-02
GO:0016831 carboxy-lyase activity 60 4 580 17 7696 3.45E-02
 
 
 
Cluster 5 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.68E-05 3 6 580 9 7696 1.23E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005055 laminin receptor activity 19 2 580 2 7696 5.67E-03
GO:0016228 aldolase activity 38 2 580 3 7696 1.62E-02
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity 54 2 580 4 7696 3.07E-02
 
 
 
Cluster 6 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.40E-04 3 17 580 77 7696 4.42E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008135 translation factor activity\, nucleic acid binding 5 13 580 66 7696 1.10E-03
GO:0003743 translation initiation factor activity 15 9 580 44 7696 4.80E-03
GO:0009055 electron carrier activity 23 4 580 11 7696 6.87E-03
 
 
 
Cluster 7 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.62E-04 7 143 580 1432 7696 9.97E-05
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003735 structural constituent of ribosome 4 19 580 102 7696 1.85E-04
GO:0003697 single-stranded DNA binding 6 7 580 24 7696 1.48E-03
GO:0003676 nucleic acid binding 26 99 580 1043 7696 7.17E-03
GO:0005198 structural molecule activity 27 42 580 380 7696 7.22E-03
GO:0045012 MHC class II receptor activity 31 4 580 12 7696 9.69E-03
GO:0008307 structural constituent of muscle 32 6 580 26 7696 1.12E-02
GO:0042809 vitamin D receptor binding 52 3 580 9 7696 2.54E-02
 
 
 
Cluster 8 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.62E-04 3 5 580 8 7696 1.11E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0005549 odorant binding 20 2 580 2 7696 5.67E-03
GO:0008121 ubiquinol-cytochrome-c reductase activity 24 3 580 6 7696 7.17E-03
GO:0016681 oxidoreductase activity\, acting on diphenols and related substances as donors\, cytochrome as acceptor 25 3 580 6 7696 7.17E-03
 
 
 
Cluster 9 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
6.20E-04 4 16 580 81 7696 2.94E-04
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004843 ubiquitin-specific protease activity 8 5 580 14 7696 2.70E-03
GO:0016721 oxidoreductase activity\, acting on superoxide radicals as acceptor 39 2 580 3 7696 1.62E-02
GO:0003729 mRNA binding 50 10 580 65 7696 2.26E-02
GO:0008143 poly(A) binding 58 2 580 4 7696 3.07E-02
 
 
 
Cluster 10 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.82E-03 3 9 580 39 7696 2.01E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004364 glutathione transferase activity 22 4 580 11 7696 6.87E-03
GO:0016765 transferase activity\, transferring alkyl or aryl (other than methyl) groups 46 5 580 22 7696 2.15E-02
GO:0019888 protein phosphatase regulator activity 61 4 580 17 7696 3.45E-02
 
 
 
Cluster 11 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.39E-03 4 8 580 33 7696 2.54E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0003954 NADH dehydrogenase activity 11 6 580 21 7696 3.64E-03
GO:0016659 oxidoreductase activity\, acting on NADH or NADPH\, other acceptor 14 6 580 22 7696 4.69E-03
GO:0016655 oxidoreductase activity\, acting on NADH or NADPH\, quinone or similar compound as acceptor 34 6 580 27 7696 1.35E-02
GO:0016830 carbon-carbon lyase activity 59 2 580 4 7696 3.07E-02
 
 
 
Cluster 12 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
1.45E-02 2 6 580 25 7696 9.17E-03
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0008137 NADH dehydrogenase (ubiquinone) activity 21 6 580 23 7696 5.95E-03
GO:0015081 sodium ion transporter activity 28 6 580 25 7696 9.17E-03
 
 
 
Cluster 13 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.05E-02 2 2 580 3 7696 1.62E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004449 isocitrate dehydrogenase (NAD+) activity 17 2 580 2 7696 5.67E-03
GO:0004448 isocitrate dehydrogenase activity 36 2 580 3 7696 1.62E-02
 
 
 
Cluster 14 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.05E-02 2 2 580 3 7696 1.62E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004776 succinate-CoA ligase (GDP-forming) activity 18 2 580 2 7696 5.67E-03
GO:0004774 succinate-CoA ligase activity 37 2 580 3 7696 1.62E-02
 
 
 
Cluster 15 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.05E-02 2 2 580 3 7696 1.62E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0046906 tetrapyrrole binding 41 2 580 3 7696 1.62E-02
GO:0020037 heme binding 40 2 580 3 7696 1.62E-02
 
 
 
Cluster 16 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.13E-02 2 3 580 8 7696 1.79E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004680 casein kinase activity 43 3 580 8 7696 1.79E-02
GO:0004681 casein kinase I activity 56 2 580 4 7696 3.07E-02
 
 
 
Cluster 17 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
2.49E-02 3 4 580 15 7696 2.23E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0015002 heme-copper terminal oxidase activity 48 4 580 15 7696 2.23E-02
GO:0004129 cytochrome-c oxidase activity 47 4 580 15 7696 2.23E-02
GO:0016676 oxidoreductase activity\, acting on heme group of donors\, oxygen as acceptor 49 4 580 15 7696 2.23E-02
 
 
 
Cluster 18 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
3.23E-02 3 5 580 24 7696 3.06E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0016209 antioxidant activity 45 5 580 22 7696 2.15E-02
GO:0004601 peroxidase activity 53 4 580 16 7696 2.80E-02
GO:0016684 oxidoreductase activity\, acting on peroxide as acceptor 62 4 580 18 7696 4.18E-02
 
 
 
Cluster 19 FDR (q-value) Terms List Hits List Total Population Hits Population Total P-value
4.45E-02 1 3 580 11 7696 4.45E-02
ID Term Rank List Hits List Total Population Hits Population Total P-values
GO:0004091 carboxylesterase activity 64 3 580 11 7696 4.45E-02