|
ECM component |
Gene ID |
Symbol |
Name |
Fold variation |
Tissular fraction |
ECM role |
|
Structural proteins |
||||||
|
|
COL6A2 |
collagen, type VI, alpha 2 |
3.68 |
SVF |
cell matrix adhesion |
|
| COL1A2 |
collagen, type I, alpha 2 |
3.47 | SVF | proper matrix | ||
| COL6A1 |
collagen, type VI, alpha 1 |
1.86 | SVF | cell matrix adhesion | ||
| COL5A2 |
collagen, type V, alpha 2 |
1.64 | SVF | proper matrix | ||
| EMILIN2 |
elastin microfibril interfacer 2 |
1.45 | SVF | proper matrix | ||
| COL6A3 |
collagen, type VI, alpha 3 |
1.23 | — | proper matrix | ||
| COL1A1 |
collagen, type I, alpha 1 |
0.89 | SVF | proper matrix | ||
| COL21A1 |
collagen, type XXI, alpha 1 |
0.84 | SVF | proper matrix | ||
| COL12A1 |
collagen, type XII, alpha 1 |
0.67 | — | proper matrix | ||
| COL4A1 |
collagen, type IV, alpha 1 |
0.61 | SVF | proper matrix | ||
| COL15A1 |
collagen, type XV, alpha 1 |
0.43 | SVF | proper matrix | ||
| ELN |
elastin (supravalvular aortic stenosis, Williams-Beuren syndrome) |
0.26 | SVF | proper matrix | ||
|
Glycoproteins |
||||||
|
LGALS3BP |
lectin, galactoside-binding, soluble, 3 binding protein |
8.00 | Adipocyte | cell cell adhesion | ||
| ITGA5 |
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
7.18 | — | cell matrix adhesion | ||
| LGALS1 |
lectin, galactoside-binding, soluble, 1 (galectin 1) |
3.95 | — | cell matrix adhesion | ||
| RECK |
reversion-inducing-cysteine-rich protein with kazal motifs |
3.42 | — | remodeling | ||
| LAMB2 |
laminin, beta 2 (laminin S) |
3.31 | — | cell matrix adhesion | ||
| LMAN1 |
lectin, mannose-binding, 1 |
3.10 | — | cell cell adhesion | ||
| ITGAM |
integrin, alpha M (complement component 3 receptor 3 subunit) |
2.85 | SVF | cell matrix adhesion | ||
| THBS2 |
thrombospondin 2 |
2.54 | SVF | cell matrix adhesion | ||
| SIGLEC6 |
sialic acid binding Ig-like lectin 6 |
2.49 | — | cell cell adhesion | ||
| LGALS8 |
lectin, galactoside-binding, soluble, 8 (galectin 8) |
2.42 | SVF | cell cell adhesion | ||
| FN1 |
fibronectin 1 |
2.28 | SVF | cell matrix adhesion | ||
| CDH13 |
cadherin 13, H-cadherin (heart) |
1.95 | SVF | cell cell adhesion | ||
| LMAN2L |
lectin, mannose-binding 2-like |
1.73 | SVF | cell cell adhesion | ||
| LAMB1 |
laminin, beta 1 |
1.59 | — | cell matrix adhesion | ||
| ITGBL1 |
integrin, beta-like 1 (with EGF-like repeat domains) |
1.53 | — | cell matrix adhesion | ||
| NID2 |
nidogen 2 (osteonidogen) |
1.51 | SVF | cell matrix adhesion | ||
| CD44 |
CD44 molecule (Indian blood group) |
1.44 | SVF | cell matrix adhesion | ||
| ITGAV |
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) |
1.25 | Adipocyte | cell matrix adhesion | ||
| LAMA3 |
laminin, alpha 3 |
1.21 | Adipocyte | cell matrix adhesion | ||
| ITGB2 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
1.19 | SVF | cell matrix adhesion | ||
| LAMA2 |
laminin, alpha 2 (merosin, congenital muscular dystrophy) |
1.06 | SVF | cell matrix adhesion | ||
| LAMA4 |
laminin, alpha 4 |
1.05 | SVF | cell matrix adhesion | ||
| THBS3 |
thrombospondin 3 |
0.40 | SVF | cell matrix adhesion | ||
| CLEC3B |
C-type lectin domain family 3, member B |
0.38 | SVF | cell cell adhesion | ||
| POSTN |
periostin, osteoblast specific factor |
0.34 | SVF | cell matrix adhesion | ||
| CNTNAP1 |
contactin associated protein 1 |
0.32 | SVF | cell matrix adhesion | ||
|
Glycosaminoglycans and proteoglycans |
||||||
| LUM |
lumican |
2.86 | SVF | proper matrix | ||
| HAPLN3 |
hyaluronan and proteoglycan link protein 3 |
2.81 | — | cell matrix adhesion | ||
| PIGT |
phosphatidylinositol glycan anchor biosynthesis, class T |
2.41 | — | remodeling | ||
| DMP1 |
dentin matrix acidic phosphoprotein |
1.97 | — | cell matrix adhesion | ||
| SGCB |
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) |
1.90 | Adipocyte | cell matrix adhesion | ||
| SDC2 |
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) |
1.41 | — | cell matrix adhesion | ||
| PIGK |
phosphatidylinositol glycan anchor biosynthesis, class K |
1.33 | — | remodeling | ||
| SDC3 |
syndecan 3 (N-syndecan) |
0.76 | SVF | cell matrix adhesion | ||
| DAG1 |
dystroglycan 1 (dystrophin-associated glycoprotein 1) |
0.66 | SVF | cell matrix adhesion | ||
| GPC3 |
glypican 3 |
0.64 | SVF | cell matrix adhesion | ||
| PIGF |
phosphatidylinositol glycan anchor biosynthesis, class F |
0.63 | — | remodeling | ||
| SPOCK1 |
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 |
0.60 | SVF | proper matrix | ||
| SDCBP |
syndecan binding protein (syntenin) |
0.55 | — | cell cell adhesion | ||
|
Enzymes |
||||||
| MMP3 |
matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
37.99 | — | remodeling | ||
| MMP1 |
matrix metallopeptidase 1 (interstitial collagenase) |
22.76 | Adipocyte | remodeling | ||
| TIMP1 |
TIMP metallopeptidase inhibitor 1 |
8.10 | SVF | remodeling | ||
| TFPI2 |
tissue factor pathway inhibitor 2 |
7.06 | SVF | remodeling | ||
| MMP9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
7.06 | SVF | remodeling | ||
| P4HA2 |
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II |
5.42 | — | remodeling | ||
| PCOLCE |
procollagen C-endopeptidase enhancer |
4.89 | SVF | remodeling | ||
| PLOD1 |
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 |
3.49 | Adipocyte | remodeling | ||
| MMP2 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
3.49 | SVF | remodeling | ||
| DPP9 |
dipeptidyl-peptidase 9 |
3.27 | — | remodeling | ||
| BMP1 |
bone morphogenetic protein 1 |
3.21 | — | remodeling | ||
| HEXA |
hexosaminidase A (alpha polypeptide) |
3.14 | SVF | remodeling | ||
| SLC35D1 |
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 |
2.65 | — | remodeling | ||
| CPM |
carboxypeptidase M |
2.63 | Adipocyte | remodeling | ||
| ST3GAL4 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
2.48 | — | remodeling | ||
| ADAM15 |
ADAM metallopeptidase domain 15 (metargidin) |
2.34 | SVF | remodeling | ||
| LOXL1 |
lysyl oxidase-like 1 |
2.34 | SVF | remodeling | ||
| ST8SIA5 |
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 |
2.29 | — | remodeling | ||
| ChGn |
chondroitin beta1,4 N-acetylgalactosaminyltransferase |
2.24 | — | remodeling | ||
| NANS |
N-acetylneuraminic acid synthase (sialic acid synthase) |
2.01 | SVF | remodeling | ||
| POMT1 |
protein-O-mannosyltransferase 1 |
2.00 | — | remodeling | ||
| MGAT2 |
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
1.95 | SVF | remodeling | ||
| PLAU |
plasminogen activator, urokinase |
1.90 | SVF | remodeling | ||
| RPN1 |
ribophorin I |
1.88 | — | remodeling | ||
| MAN2B2 |
mannosidase, alpha, class 2B, member 2 |
1.85 | — | remodeling | ||
| SULF1 |
sulfatase 1 |
1.85 | SVF | remodeling | ||
| CTSS |
cathepsin S |
1.80 | SVF | remodeling | ||
| CHST12 |
carbohydrate (chondroitin 4) sulfotransferase 12 |
1.73 | SVF | remodeling | ||
| MMP7 |
matrix metallopeptidase 7 (matrilysin, uterine) |
1.67 | SVF | remodeling | ||
| B3GALT4 |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 |
1.56 | — | remodeling | ||
| ST6GAL1 |
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
1.55 | SVF | remodeling | ||
| ADAM17 |
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) |
1.48 | SVF | remodeling | ||
| CTSF |
cathepsin F |
1.45 | Adipocyte | remodeling | ||
| TIMP2 |
TIMP metallopeptidase inhibitor 2 |
1.45 | SVF | remodeling | ||
| ADAM9 |
ADAM metallopeptidase domain 9 (meltrin gamma) |
1.42 | SVF | remodeling | ||
| TMPRSS2 |
transmembrane protease, serine 2 |
1.40 | — | remodeling | ||
| STT3B |
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) |
1.31 | — | remodeling | ||
| ADAM22 |
ADAM metallopeptidase domain 22 |
1.30 | SVF | cell matrix adhesion | ||
| EXTL2 |
exostoses (multiple)-like 2 |
1.30 | SVF | remodeling | ||
| LARGE |
like-glycosyltransferase |
1.29 | SVF | remodeling | ||
| P4HB |
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide |
1.28 | — | remodeling | ||
| GAL3ST1 |
galactose-3-O-sulfotransferase 1 |
1.26 | SVF | remodeling | ||
| DPP8 |
dipeptidyl-peptidase 8 |
1.25 | — | remodeling | ||
| ST3GAL5 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
1.24 | SVF | remodeling | ||
| CD37 |
CD37 molecule |
1.23 | SVF | remodeling | ||
| CTSD |
cathepsin D (lysosomal aspartyl peptidase) |
1.20 | Adipocyte | remodeling | ||
| B3GALT6 |
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 |
1.20 | SVF | remodeling | ||
| ADAM12 |
ADAM metallopeptidase domain 12 (meltrin alpha) |
1.14 | Adipocyte | remodeling | ||
| PLOD3 |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
1.12 | SVF | remodeling | ||
| ARSB |
arylsulfatase B |
1.09 | — | remodeling | ||
| MGAT3 |
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase |
1.09 | SVF | remodeling | ||
| PLAUR |
plasminogen activator, urokinase receptor |
1.07 | SVF | remodeling | ||
| PPP2R1A |
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform |
1.05 | — | cell matrix adhesion | ||
| ADAM19 |
ADAM metallopeptidase domain 19 (meltrin beta) |
0.84 | SVF | remodeling | ||
| PIGB |
phosphatidylinositol glycan anchor biosynthesis, class B |
0.74 | Adipocyte | remodeling | ||
| ADAMTS1 |
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
0.74 | SVF | remodeling | ||
| EXT2 |
exostoses (multiple) 2 |
0.72 | — | remodeling | ||
| GUSB |
glucuronidase, beta |
0.70 | SVF | remodeling | ||
| NPEPL1 |
aminopeptidase-like 1 |
0.67 | Adipocyte | remodeling | ||
| B4GALT4 |
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 |
0.66 | — | remodeling | ||
| FUCA1 |
fucosidase, alpha-L- 1, tissue |
0.60 | SVF | remodeling | ||
| ACHE |
acetylcholinesterase (Yt blood group) |
0.52 | — | cell cell adhesion | ||
| HS3ST4 |
heparan sulfate (glucosamine) 3-O-sulfotransferase 4 |
0.48 | Adipocyte | remodeling | ||
| OMA1 |
OMA1 homolog, zinc metallopeptidase (S. cerevisiae) |
0.27 | — | remodeling | ||
| MGAT5 |
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase |
0.24 | — | remodeling | ||
| ST6GALNAC5 |
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta- galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 |
0.12 | SVF | remodeling | ||
|
Other components |
||||||
| CRISPLD2 |
cysteine-rich secretory protein LCCL domain containing 2 |
4.01 | SVF | cell cell adhesion | ||
| TNC |
tenascin C (hexabrachion) |
3.57 | SVF | cell matrix adhesion | ||
| F3 |
coagulation factor III (thromboplastin, tissue factor) |
3.51 | — | remodeling | ||
| CYR61 |
cysteine-rich, angiogenic inducer, 61 |
3.42 | Adipocyte | cell cell adhesion | ||
| EFEMP2 |
EGF-containing fibulin-like extracellular matrix protein 2 |
3.07 | Adipocyte | proper matrix | ||
| ESM1 |
endothelial cell-specific molecule 1 |
2.50 | — | proper matrix | ||
| SPG7 |
spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) |
2.45 | — | cell matrix adhesion | ||
| ADRM1 |
adhesion regulating molecule 1 |
2.38 | — | cell matrix adhesion | ||
| CD99 |
CD99 molecule |
2.24 | SVF | cell matrix adhesion | ||
| CNTN2 |
contactin 2 (axonal) |
2.10 | — | cell matrix adhesion | ||
| CEACAM1 |
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) |
2.10 | — | cell matrix adhesion | ||
| ECM1 |
extracellular matrix protein 1 |
2.06 | SVF | proper matrix | ||
| PANX1 |
pannexin 1 |
2.06 | SVF | cell cell adhesion | ||
| BSG |
basigin (Ok blood group) |
1.95 | Adipocyte | cell matrix adhesion | ||
| ICAM1 |
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor |
1.86 | SVF | cell cell adhesion | ||
| ROBO1 |
roundabout, axon guidance receptor, homolog 1 (Drosophila) |
1.83 | — | cell matrix adhesion | ||
| RELN |
reelin |
1.76 | — | cell matrix adhesion | ||
| F13A1 |
coagulation factor XIII, A1 polypeptide |
1.55 | SVF | remodeling | ||
| DCBLD2 |
discoidin, CUB and LCCL domain containing 2 |
1.50 | — | cell matrix adhesion | ||
| MPZL1 |
myelin protein zero-like 1 |
1.50 | SVF | cell matrix adhesion | ||
| WISP2 |
WNT1 inducible signaling pathway protein 2 |
1.33 | SVF | cell matrix adhesion | ||
| GJA1 |
gap junction protein, alpha 1, 43kDa (connexin 43) |
1.32 | SVF | cell cell adhesion | ||
| FSTL1 |
follistatin-like 1 |
1.21 | SVF | cell matrix adhesion | ||
| ICAM3 |
intercellular adhesion molecule 3 |
0.86 | — | cell cell adhesion | ||
| VEZT |
vezatin, adherens junctions transmembrane protein |
0.72 | — | cell cell adhesion | ||
| MAGI1 |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
0.55 | Adipocyte | cell matrix adhesion | ||
| GJA12 |
gap junction protein, alpha 12, 47kDa |
0.44 | SVF | cell cell adhesion | ||
|
SYMPK |
symplekin |
0.40 |
Adipocyte |
cell cell adhesion |
||
| Inflammatory molecules | Gene ID | Symbol | Name | Fold variation | Tissular fraction | |
|
Interferon family |
||||||
| 8519 | IFITM1 | interferon induced transmembrane protein 1 (9-27) | 5.02 | SVF | ||
| 359948 | IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 4.4 | SVF | ||
| 3662 | IRF4 | interferon regulatory factor 4 | 2.41 | Adipocyte | ||
| 3665 | IRF7 | interferon regulatory factor 7 | 3.67 | SVF | ||
| 3429 | IFI27 | interferon, alpha-inducible protein 27 | 4.19 | SVF | ||
| 2537 | IFI6 | interferon, alpha-inducible protein 6 | 3.11 | SVF | ||
|
Interleukins |
||||||
| 9173 | IL1RL1 | interleukin 1 receptor-like 1 | 1.73 | — | ||
| 3598 | IL13RA2 | interleukin 13 receptor, alpha 2 | 4.51 | Adipocyte | ||
| 11009 | IL24 | interleukin 24 | 6.4 | SVF | ||
| 9235 | IL32 | interleukin 32 | 8.64 | SVF | ||
| 259307 | IL4I1 | interleukin 4 induced 1 | 1.92 | — | ||
| 3566 | IL4R | interleukin 4 receptor | 3.01 | SVF | ||
| 3569 | IL6 | interleukin 6 (interferon, beta 2) | 6.46 | SVF | ||
| 3575 | IL7R | interleukin 7 receptor | 2.1 | SVF | ||
|
Prostaglandins |
||||||
| 9536 | PTGES | prostaglandin E synthase | 5.23 | SVF | ||
| 5743 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 14.1 | SVF | ||
|
Acute phase proteins |
||||||
| 6288 | SAA1 | serum amyloid A1 | 7.5 | — | ||
| 6289 | SAA2 | serum amyloid A2 | 9.16 | Adipocyte | ||
| 567 | B2M | beta-2-microglobulin | 2.84 | SVF | ||
| 6352 | CCL5 | chemokine (C-C motif) ligand 5 | 19.51 | SVF | ||
| 9618 | TRAF4 | TNF receptor-associated factor 4 | 2.9 | SVF | ||
| 7128 | TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 2.19 | SVF | ||
| 7130 | TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 4.57 | SVF | ||
|
Complement family |
||||||
| 1380 | CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 1.74 | — | ||
| 715 | C1R | complement component 1, r subcomponent | 2.51 | — | ||
| 629 | CFB | complement factor B | 4.1 | SVF | ||
|
Others |
||||||
| 151647 | FAM19A4 | family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 | 3.33 | — | ||
| 2191 | FAP | fibroblast activation protein, alpha | 2.26 | Adipocyte | ||
| 2247 | FGF2 | fibroblast growth factor 2 (basic) | 2.84 | — | ||
| 9446 | GSTO1 | glutathione S-transferase omega 1 | 3.17 | — | ||
| SVF = Stroma Vascular Fraction | ||||||
| The indicated fold variations were measured in the cDNA microarray experiments. | ||||||