|
Phenotype
|
Mean
(T0)
|
Mean
(3M)
|
∆
|
|
n
|
10
|
10
|
—
|
|
F/M
|
10/0
|
—
|
—
|
|
Age (years)
|
41.5 ± 4.0
|
—
|
—
|
|
Weight (kg)
|
123.1 ± 1.6
|
104.5 ± 1.7
|
-18.53*
|
|
BMI (kg/m²)
|
47.6 ± 4.3
|
40.6 ± 4.9
|
-7.02*
|
|
Glucose homeostasis
|
|
|
|
|
Glucose (mmol/l)
|
5.51 ± 0.38
|
4.99 ± 0.21
|
-0.52*
|
|
Insulin (µU/ml)
|
12.8 ± 3.5
|
7.2 ± 1.1
|
-5.61*
|
|
QUICKI
|
0.33 ± 0.02
|
0.37 ± 0.02
|
0.04*
|
|
Type 2 diabetes
|
|
|
|
|
Glycemia >7 mmol/l
or treatment
|
1 (10%)
|
0
|
-1 (10%)
|
|
Lipid homeostasis
|
|
|
|
|
Cholesterol (mmol/l)
|
5.18 ± 0.31
|
4.84 ± 0.30
|
-0.34
|
|
HDL cholesterol
(mmol/l)
|
1.30 ± 0.06
|
1.28 ± 0.09
|
-0.02
|
|
Triglycerides (mmol/l)
|
1.25 ± 0.17
|
1.31 ± 0.22
|
0.06
|
|
Adipokines
|
|
|
|
|
Leptin (ng/ml)
|
51.9 ± 3.4
|
31.0 ± 4.1
|
-20.93*
|
|
Adiponectin (µg/ml)
|
7.18 ± 0.72
|
8.34 ± 1.22
|
1.16
|
|
Risk factors
|
|
|
|
|
HDL <1.03 mmol/l
(M), <1.29 mmol/l (F)
|
3 (30%)
|
0
|
-3 (30%)
|
|
Hypertension
≥130/85 mmHg
|
3 (30%)
|
2 (20%)
|
-1 (10%)
|
|
Glucose ≥5.6
mmol/l
|
3 (30%)
|
1 (10%)
|
-2 (20%)
|
|
Triglycerides
≥1.7 mmol/l
|
1 (10%)
|
1 (10%)
|
0
|
|
Inflammatory factors
|
|
|
|
|
TNF-α (pg/ml)
|
1.84 ± 0.11
|
1.77 ± 0.14
|
-0.07
|
|
Interleukin 6 (pg/ml)
|
2.01 ± 0.29
|
1.83 ± 0.34
|
-0.18
|
|
High-sensitivity CRP
(mg/dl)
|
30.0 ± 9.6
|
5.6 + 1.1
|
-24.33**
|
|
Orosomucoid (g/l)
|
1.03 ± 0.05
|
0.87 + 0.05
|
-0.16*
|
|
Serum amyloid A (µg/ml)
|
35.15 ± 10.13
|
12.62 ± 3.5
|
-22.53**
|
|
Hepatic factors
|
|
|
|
|
AST (IU/l)
|
20.4 ± 2.53
|
20.1 ± 2.17
|
-0.3
|
|
Alanine
aminotransferase (IU/l)
|
35.8 ± 7.24
|
25 ± 4.38
|
-10.8
|
|
γGT (mg/dl)
|
43.4 ± 11.11
|
21.33 ± 3.31
|
-22.07*
|
|
*
indicates a bilateral significance p-value <0.05 of the difference between
the two groups
** indicates
a bilateral significance p-value <0.01 of the difference between the two
groups
|
