|
ECM component |
GeneID |
Symbol |
Name |
Fold variation |
Tissular fraction |
ECM role |
|
Structural proteins |
||||||
|
|
COL12A1 |
collagen,
type XII, alpha 1 |
2.24 |
— |
proper
matrix |
|
|
|
COL5A2 |
collagen,
type V, alpha 2 |
1.79 |
SVF |
proper
matrix |
|
|
|
COL4A1 |
collagen,
type IV, alpha 1 |
1.77 |
SVF** |
proper
matrix |
|
|
|
COL1A1 |
collagen,
type I, alpha 1 |
0.64* |
SVF |
proper
matrix |
|
|
Glycoproteins |
||||||
|
|
ITGAV |
integrin, alpha V (vitronectin receptor,
alpha polypeptide, antigen CD51) |
2.01* |
Adipocyte** |
cell
matrix adhesion |
|
|
|
ITGB1 |
integrin, beta 1 (fibronectin receptor, beta
polypeptide, antigen CD29 includes MDF2, MSK12) |
1.96* |
Adipocyte** |
cell
matrix adhesion |
|
|
|
CLEC4A |
C-type lectin domain family 4, member A |
1.81 |
SVF |
cell cell adhesion |
|
|
|
ITGAM |
integrin, alpha M (complement component 3 receptor 3 subunit) |
1.61 |
SVF |
cell
matrix adhesion |
|
|
|
ITGB2 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
|
1.52 |
SVF |
cell
matrix adhesion |
|
|
|
ITGB5 |
integrin, beta 5 |
1.48 |
— |
cell
matrix adhesion |
|
|
|
LAMB1 |
laminin, beta 1 |
1.46 |
— |
cell
matrix adhesion |
|
|
|
CNTNAP1 |
contactin associated protein 1 |
1.26 |
SVF |
cell
matrix adhesion |
|
|
|
TNXB |
tenascin XB |
0.78 |
SVF |
cell
matrix adhesion |
|
|
|
LGALS3BP |
lectin, galactoside-binding, soluble,
3 binding protein |
0.68 |
Adipocyte |
cell cell adhesion |
|
|
LGALS1 |
lectin, galactoside-binding,
soluble, 1 (galectin 1) |
0.64 |
— |
cell
matrix adhesion |
||
|
|
AZGP1 |
alpha-2-glycoprotein
1, zinc |
0.53 |
Adipocyte |
cell
matrix adhesion |
|
|
Glycosaminoglycans and proteoglycans |
||||||
|
|
SDCBP |
syndecan binding protein (syntenin) |
2.48 |
— |
cell cell adhesion |
|
|
|
LUM |
lumican |
1.67 |
SVF |
proper
matrix |
|
|
Enzymes |
||||||
|
|
TFPI2 |
tissue
factor pathway inhibitor 2 |
1.74 |
SVF |
remodeling
|
|
|
|
RPN1 |
ribophorin I |
1.61 |
— |
remodeling
|
|
|
|
ADAM12 |
ADAM metallopeptidase domain 12 (meltrin
alpha) |
1.61 |
Adipocyte |
remodeling
|
|
|
|
LOX |
lysyl oxidase |
1.53 |
SVF |
remodeling
|
|
|
|
CTSS |
cathepsin S |
1.49* |
SVF** |
remodeling
|
|
|
P4HA2 |
procollagen-proline,
2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II |
1.47 |
— |
remodeling
|
||
|
|
CHSY1 |
carbohydrate
(chondroitin) synthase 1 |
1.44 |
— |
remodeling
|
|
|
|
OMA1 |
OMA1
homolog, zinc metallopeptidase (S. cerevisiae) |
1.42 |
— |
remodeling
|
|
|
|
ADAM9 |
ADAM metallopeptidase domain 9 (meltrin
gamma) |
1.41 |
SVF |
remodeling
|
|
|
|
GALNACT-2 |
chondroitin sulfate GalNAcT-2 |
1.4 |
SVF |
remodeling
|
|
|
|
ADAM17 |
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha,
converting enzyme) |
0.79 |
SVF |
remodeling
|
|
|
|
ST3GAL6 |
ST3
beta-galactoside alpha-2,3-sialyltransferase 6 |
0.77 |
— |
remodeling
|
|
|
|
ST6GALNA |
ST6
(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) N-acetylgalactosaminide
alpha-2,6-sialyltransferase 6 |
0.76 |
— |
remodeling
|
|
|
|
PLOD1 |
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 |
0.76 |
Adipocyte |
remodeling
|
|
|
|
ADAM15 |
ADAM metallopeptidase domain 15 (metargidin)
|
0.71 |
SVF |
remodeling
|
|
|
|
CPM |
carboxypeptidase M |
0.63 |
Adipocyte |
remodeling
|
|
|
Other components |
||||||
|
|
DCBLD2 |
discoidin, CUB and LCCL domain containing 2 |
1.87 |
— |
cell
matrix adhesion |
|
|
|
ESM1 |
endothelial
cell-specific molecule 1 |
1.38 |
— |
proper
matrix |
|
|
|
MAGI1 |
membrane
associated guanylate kinase,
WW and PDZ domain containing 1 |
0.76 |
Adipocyte |
cell
matrix adhesion |
|
|
|
SYMPK |
symplekin |
0.76 |
Adipocyte |
cell cell adhesion |
|
|
|
GJA12 |
gap
junction protein, alpha 12, 47kDa |
0.75 |
SVF |
cell cell adhesion |
|
|
|
GJA4 |
gap
junction protein, alpha 4, 37kDa (connexin 37) |
0.74 |
SVF |
cell cell adhesion |
|
|
F3 |
coagulation factor III (thromboplastin, tissue
factor) |
0.72 |
— |
remodeling
|
||
|
|
PRELP |
proline/arginine-rich end leucine-rich repeat
protein |
0.73 |
Adipocyte |
cell
matrix adhesion |
|
|
SVF = Stroma Vascular Fraction The indicated fold variations were measured in the cDNA microarray experiments. * Using RTqPCR, the change in expression of these genes was
confirmed in 10 independent obese and non obese subjects. We also measured a
significant change of fibronectin gene expression
level (fold increase in obese/lean subjects: 3.9, p<0.05). |
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