|
Phenotype
|
Obese
subjects
|
Lean
controls
|
|
n
|
25
|
10
|
|
F/M
|
25/0
|
10/0
|
|
Age (years)
|
40.36 ± 8.02
|
35.2 ± 7.69
|
|
BMI (kg/m²)
|
40.58 ± 1.58**
|
23.67 ± 0.48
|
|
Glucose homeostasis
|
|
|
Glucose (mmol/l)
|
5.31 ± 0.15
|
4.82 ± 0.45
|
|
Insulin (µU/ml)
|
12.53 ± 1.38
|
7.20 ± 1.56
|
|
QUICKI
|
0.33 ± 0.01
|
0.36 ± 0.02
|
|
Type 2 diabetes
|
|
|
Glycemia >7 mmol/l
or treatment
|
6 (11%)
|
0
|
|
Lipid homeostasis
|
|
|
|
Cholesterol (mmol/l)
|
5.42 ± 0.17*
|
4.36 ± 0.47
|
|
HDL cholesterol (mmol/l)
|
1.28 ± 0.08
|
1.43 ± 0.1
|
|
Triglycerides (mmol/l)
|
1.40 ± 0.11**
|
0.45 ± 0.05
|
|
Adipokines
|
|
|
Leptin (ng/ml)
|
51.84 ± 3.86
|
11.24 ± 0.35
|
|
Adiponectin (µg/ml)
|
4.54 ± 0.53
|
—
|
|
Risk factors
|
|
|
HDL <1.03 mmol/l
(M), <1.29 mmol/l (F)
|
8 (32%)
|
1 (10%)
|
|
Hypertension
≥130/85 mmHg
|
8 (32%)
|
0
|
|
Glucose ≥5.6 mmol/l
|
6 (24%)
|
1 (10%)
|
|
Triglycerides
≥1.7 mmol/l
|
5 (20%)
|
0
|
|
Inflammatory factors
|
|
|
TNF-α (pg/ml)
|
1.46 ± 0.20
|
—
|
|
Interleukin 6 (pg/ml)
|
2.92 ± 0.56
|
—
|
|
High-sensitivity CRP
(mg/dl)
|
4.36 ± 0.43
|
—
|
|
Orosomucoid (g/l)
|
0.99 ± 0.18
|
—
|
|
Serum amyloid A
(µg/ml)
|
6.33 ± 1.26
|
—
|
|
Hepatic factors
|
|
|
AST (IU/l)
|
22.66 ± 6.87
|
—
|
|
Alanine aminotransferase
(IU/l)
|
35.72 ± 18.56
|
—
|
|
γGT (mg/dl)
|
45.91 ± 46.43
|
—
|
|
* indicates a
bilateral significance p-value <0.05 of the difference between the two groups
** indicates a bilateral significance p-value <0.001 of the difference between
the two groups
The “—” sign indicates parameters which were not available for the lean
controls group. |
